Application | Comment | Organism |
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medicine | hepatic PSAT1 expression and liver serine levels are reduced in genetically engineered leptin receptor-deficient (db/db) mice and high-fat diet (HFD)-induced diabetic mice. Overexpression of PSAT1 by adenovirus expressing PSAT1 improves insulin signaling and insulin sensitivity in vitro and in vivo under normal conditions. Opposite effects are observed when PSAT1 is knocked down by small hairpin RNA specific for PSAT1. Overexpression of PSAT1 also significantly ameliorates insulin resistance in diabetic mice. PSAT1 inhibits the expression of hepatic tribbles homolog TRB3 in vitro and in vivo. Serine mediates PSAT1 regulation of TRB3 expression and insulin signaling in vitro | Homo sapiens |
Organism | UniProt | Comment | Textmining |
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Homo sapiens | - |
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Source Tissue | Comment | Organism | Textmining |
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General Information | Comment | Organism |
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physiological function | hepatic PSAT1 expression and liver serine levels are reduced in genetically engineered leptin receptor-deficient (db/db) mice and high-fat diet (HFD)-induced diabetic mice. Overexpression of PSAT1 by adenovirus expressing PSAT1 improves insulin signaling and insulin sensitivity in vitro and in vivo under normal conditions. Opposite effects are observed when PSAT1 is knocked down by small hairpin RNA specific for PSAT1. Overexpression of PSAT1 also significantly ameliorates insulin resistance in diabetic mice. PSAT1 inhibits the expression of hepatic tribbles homolog TRB3 in vitro and in vivo. Serine mediates PSAT1 regulation of TRB3 expression and insulin signaling in vitro | Homo sapiens |