Literature summary for 2.6.1.52 extracted from

Liu, B.; Jia, Y.; Cao, Y.; Wu, S.; Jiang, H.; Sun, X.; Ma, J.; Yin, X.; Mao, A.; Shang, M.
Overexpression of phosphoserine aminotransferase 1 (PSAT1) predicts poor prognosis and associates with tumor progression in human esophageal squamous cell carcinoma (2016), Cell. Physiol. Biochem., 39, 395-406.

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Application

Application	Comment	Organism
medicine	isoform PSAT1 expression is elevated in esophageal squamous cell carcinoma tissues compared to normal esophageal tissues. Increased PSAT1 expression is significantly associated with stage of disease, lymph node metastasis, distant metastasis and poor prognosis. In vitro, PSAT1 overexpression promotes esophageal squamous cell carcinoma cell proliferation and matrigel invasion. In vivo, injection of mice with esophageal squamous cell carcinoma cells overexpressing PSAT1 enhances tumor formation. PSAT1 upregulatesthe expression and/or activity of GSK3beta/Snail	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
esophageal squamous cell carcinoma cell	-	Homo sapiens	-
HEK-293T cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
PSAT1	-	Homo sapiens

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Release 2023.1 (January 2023)