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Literature summary for 2.6.1.52 extracted from

  • Basurko, M.J.; Marche, M.; Darriet, M.; Cassaigne, A.
    Phosphoserine aminotransferase, the second step-catalyzing enzyme for serine biosynthesis (1999), IUBMB Life, 48, 525-529.
    View publication on PubMed
Search for more literature for 2.6.1.52

Inhibitors

Inhibitors Comment Organism Structure
2-oxoglutarate
-
 Bos taurus
L-glutamate
-
 Bos taurus
L-phosphoserine product inhibition Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
 3-phosphohydroxypyruvate pH 7.5, 30°C Bos taurus
0.035
-
 L-phosphoserine pH 7.5, 30°C Bos taurus
0.8
-
 2-oxoglutarate pH 7.5, 30°C Bos taurus
1.2
-
 L-glutamate pH 7.5, 30°C Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
43000
-
 2 * 43000, SDS-PAGE Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 bovine
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
15
-
-
 Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate + 3-phosphohydroxypyruvate
-
 Bos taurus O-phospho-L-serine + 2-oxoglutarate
-
 r

Subunits

Subunits Comment Organism
dimer 2 * 43000, SDS-PAGE Bos taurus

Synonyms

Synonyms Comment Organism
PSerAT
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate Km 0.005 mM Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.045
-
 L-phosphoserine pH 7.5, 30°C Bos taurus
2.55
-
 2-oxoglutarate pH 7.5, 30°C Bos taurus
7.42
-
 L-glutamate pH 7.5, 30°C Bos taurus