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Literature summary for 2.6.1.51 extracted from
- In vitro association with peroxisomes and conformational change of peroxisomal serine:pyruvate/alanine:glyoxylate aminotransferase in rat and human livers (1996), Biochem. Biophys. Res. Commun., 228, 341-346.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | absence of human SPT/AGT or mistargeting of this enzyme causes primary hyperoxaluria type 1, an inborn error of glyoxylate metabolism characterized by increased oxalate production | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| plasmid containing cDNA of human SPT cloned | Homo sapiens |
General Stability
| General Stability | Organism |
|---|---|
| enzyme recovered in the supernatant is resistant to proteinase K in presence or absence of Triton X-100, enzyme recovered in the precipitate is sensitive to the protease | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| peroxisome | - |
Homo sapiens | 5777 | - |
| peroxisome | - |
Rattus norvegicus | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43000 | - |
2 * 43000, SDS-PAGE | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | class IV aminotransferase, identical with EC 2.6.1.44 | Homo sapiens | ? | - |
? |  |
| additional information | class IV aminotransferase, identical with EC 2.6.1.44 | Rattus norvegicus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 43000, SDS-PAGE | Rattus norvegicus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| serine:pyruvate/alanine:glyoxylate aminotransferase | - |
Homo sapiens |
| serine:pyruvate/alanine:glyoxylate aminotransferase | - |
Rattus norvegicus |
| SPT/AGT | - |
Homo sapiens |
| SPT/AGT | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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