Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.6.1.5 extracted from

  • Ohisalo, J.J.; Andersson, S.M.; Pispa, J.P.
    Partial purification and properties of frog liver tyrosine aminotransferase (1977), Biochem. J., 163, 411-417.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.6.1.5

Activating Compound

Activating Compound Comment Organism Structure
adrenaline activation is independent of the concentration of tyrosine, maximal activation achieved with 7-10 micromolar of adrenaline Rana temporaria
dopamine slight activation Rana temporaria
metanephrine slight activation Rana temporaria
noradrenaline slight activation Rana temporaria

Inhibitors

Inhibitors Comment Organism Structure
Aminooxyacetate probably acts reacting with the cofactor Rana temporaria
Canaline probably acts reacting with the cofactor Rana temporaria
homogentisate half-maximal inhibition with 15 micromolar Rana temporaria

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information non-Michaelis complex kinetic Rana temporaria

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
85000
-
 gel filtration, isoforms I and II Rana temporaria

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tyrosine + 2-oxoglutarate Rana temporaria
-
 4-hydroxyphenylpyruvate + L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Rana temporaria
-
 frog
-

Purification (Commentary)

Purification (Comment) Organism
partial purification of two isoenzymes, using several chromatographic steps Rana temporaria

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rana temporaria
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
203
-
 isoenzyme I Rana temporaria

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tyrosine + 2-oxoglutarate
-
 Rana temporaria 4-hydroxyphenylpyruvate + L-glutamate
-
 ?
L-tyrosine + 2-oxoglutarate specific for 2-oxoglutarate as the amino group acceptor Rana temporaria 4-hydroxyphenylpyruvate + L-glutamate
-
 ?
L-tyrosine + oxaloacetate no activity Rana temporaria 4-hydroxyphenylpyruvate + L-aspartate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rana temporaria