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Literature summary for 2.6.1.5 extracted from

  • Iwasaki, Y.; Lamar, C.; Danenberg, K.; Pitot, H.C.
    Studies on the induction and repression of enzymes in rat liver. Characterization and metabolic regulation of multiple forms of tyrosine aminotransferase (1973), Eur. J. Biochem., 34, 347-357.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
L-glutamate
-
Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.9
-
2-oxoglutarate pH 7.6, 37°C, enzyme form I Rattus norvegicus
1
-
2-oxoglutarate pH 7.6, 37°C, enzyme form III Rattus norvegicus
1.1
-
2-oxoglutarate pH 7.6, 37°C, enzyme form II Rattus norvegicus
1.2
-
2-oxoglutarate pH 7.6, 37°C, enzyme form IV Rattus norvegicus
1.4
-
L-tyrosine pH 7.6, 37°C, enzyme form II Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
107000
-
gel filtration, different isoenzymes Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
4 enzyme forms from kidney, heart and brain
-

Purification (Commentary)

Purification (Comment) Organism
separation of 4 enzyme forms: I, II, III, IV, using hydroxyapatite chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Rattus norvegicus
-
kidney
-
Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
effect of glucagon, cyclic nucletides, insulin and hydrocortisone on activity Rattus norvegicus
additional information
-
activities of different isoenzymes from liver, kidney and heart Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-phenylalanine + 2-oxoglutarate
-
Rattus norvegicus phenylpyruvate + L-glutamate
-
?
L-tyrosine + 2-oxoglutarate
-
Rattus norvegicus 4-hydroxyphenylpyruvate + L-glutamate
-
?
tryptophan + 2-oxoglutarate
-
Rattus norvegicus 3-indole-2-oxopropanoate + L-glutamate
-
?

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxamine 5'-phosphate can replace pyridoxal 5'-phosphate Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
20.3
-
L-glutamate pH 7.6, 37°C, isozyme I from kidney, L-tyrosine as substrate Rattus norvegicus
26.8
-
L-glutamate pH 7.6, 37°C, isozyme IV from liver, L-tyrosine as substrate Rattus norvegicus
27.4
-
L-glutamate pH 7.6, 37°C, isozyme III from liver, L-tyrosine as substrate Rattus norvegicus
31.3
-
L-glutamate pH 7.6, 37°C, isozyme II from liver, L-tyrosine as substrate Rattus norvegicus