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Literature summary for 2.6.1.44 extracted from

  • Bertoldi, M.; Cellini, B.; Paiardini, A.; Montioli, R.; Borri Voltattorni, C.
    Reactions of human liver peroxisomal alanine:glyoxylate aminotransferase with beta -chloro-L-alanine and L-cysteine: Spectroscopic and kinetic analysis (2008), Biochim. Biophys. Acta, 1784, 1356-1362.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1
-
L-cysteine pH 7.4, Km value of L-cysteine is decreased by 40fold and 200fold in comparison with those of L-alanine and L-serine Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
peroxisome
-
Homo sapiens 5777
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P21549
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-cysteine + pyruvate
-
Homo sapiens 3-mercapto-2-oxopropanoate + L-alanine enzyme catalyzes both beta-elimination and half-transamination of L-cysteine together with pyruvate transamination via a ketimine common intermediate. L-cysteine partitions between the two reactions with a ratio of 2.5 ?
additional information alanine:glyoxylate aminotransferase is able to catalyze the alpha,beta-elimination of beta-chloro-L-alanine with a catalytic efficiency similar to that of the physiological transaminase reaction with L-alanine. The enzyme catalyzes both the alpha,beta-elimination and half-transamination of the natural amino acid L-cysteine together with pyruvate half-transamination Homo sapiens ?
-
?
additional information enzyme is able to catalyze the alpha,beta-elimination of beta-chloro-L-alanine with a kcat value of 0.74 per s and a Km value of 0.51 mM Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
alanine:glyoxylate aminotransferase
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.22
-
L-cysteine pH 7.4 Homo sapiens