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Literature summary for 2.6.1.43 extracted from
- Evidence of hemin as an end product inhibitor of L-alanine: 4,5-dioxovalerate transaminase in rat liver mitochondria (1985), FEBS Lett., 189, 129-132.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| hemin | - |
Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-alanine + 4,5-dioxopentanoate | Rattus norvegicus | heme biosynthetic pathway | 5-aminolevulinate + pyruvate | - |
ir | |
| L-alanine + 4,5-dioxopentanoate | Rattus norvegicus Wistar | heme biosynthetic pathway | 5-aminolevulinate + pyruvate | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Wistar | - |
| Rattus norvegicus Wistar | - |
Wistar | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-alanine + 4,5-dioxopentanoate | - |
Rattus norvegicus | 5-aminolevulinate + pyruvate | - |
ir | |
| L-alanine + 4,5-dioxopentanoate | heme biosynthetic pathway | Rattus norvegicus | 5-aminolevulinate + pyruvate | - |
ir | |
| L-alanine + 4,5-dioxopentanoate | - |
Rattus norvegicus Wistar | 5-aminolevulinate + pyruvate | - |
ir | |
| L-alanine + 4,5-dioxopentanoate | heme biosynthetic pathway | Rattus norvegicus Wistar | 5-aminolevulinate + pyruvate | - |
ir | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 30 | - |
hemin | different concentrations of alanine at fixed 4,5-dioxopentanoate concentration | Rattus norvegicus | |
| 42 | - |
hemin | different concentrations of 4,5-dioxopentanoate concentration at fixed alanine concentration | Rattus norvegicus | |
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