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Literature summary for 2.6.1.43 extracted from

  • Noguchi, T.; Mori, R.
    Biosynthesis of porphyrin precursors in mammals. Identity of alanine: gamma, delta-dioxovalerate aminotransferase with alanine:glyoxylate aminotransferase (1981), J. Biol. Chem., 256, 10335-10339.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
glyoxylic acid competitive inhibition Bos taurus
hydroxylamine
-
Bos taurus
Isonicotinic acid hydrazide
-
Bos taurus
potassium cyanide
-
Bos taurus
Semicarbazide
-
Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.3
-
4,5-Dioxopentanoate pH 7.0, 37°C Bos taurus
0.67
-
glyoxylate pH 7.0, 37°C Bos taurus
2.5
-
L-alanine pH 7.0, 37°C, 4,5-dioxopentanoate as amino acceptor Bos taurus
4
-
L-alanine pH 7.0, 37°C, glyoxylate as amino acceptor Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Bos taurus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
58000
-
4 * 58000, SDS-PAGE Bos taurus
238000
-
gel filtration Bos taurus
240000
-
-
Bos taurus
245000
-
sucrose density gradient centrifugation Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-alanine + 4,5-dioxopentanoate Bos taurus biosynthesis of porphyrin precursors 5-aminolevulinate + pyruvate
-
ir

Organism

Organism UniProt Comment Textmining
Bos taurus
-
bovine
-

Purification (Commentary)

Purification (Comment) Organism
-
Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.753
-
-
Bos taurus

Storage Stability

Storage Stability Organism
-20°C, purified enzyme in 50 mM potassium phosphate buffer, pH 7.5, 10% glycerol, may be stored for at least 8 weeks without loss of either activity Bos taurus
0-5°C, 50 mM potassium phosphate buffer, pH 7.5, 10% glycerol, stored for 2 weeks, little or none of each activity is lost Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycine + 4,5-dioxopentanoate
-
Bos taurus 5-aminolevulinate + glyoxylate
-
?
L-alanine + 4,5-dioxopentanoate
-
Bos taurus 5-aminolevulinate + pyruvate
-
ir
L-alanine + 4,5-dioxopentanoate biosynthesis of porphyrin precursors Bos taurus 5-aminolevulinate + pyruvate
-
ir

Subunits

Subunits Comment Organism
tetramer 4 * 58000, SDS-PAGE Bos taurus

Synonyms

Synonyms Comment Organism
EC 2.6.1.44 alanine-glyoxylate transaminase and aminolevulinate transaminase activities reside in the same protein Bos taurus
EC 2.6.1.44 identical with alanine-glyoxylate aminotransferase Bos taurus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
10 min, about 65% loss of activity Bos taurus