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Literature summary for 2.6.1.42 extracted from

  • Goto, M.; Miyahara, I.; Hayashi, H.; Kagamiyama, H.; Hirotsu, K.
    Crystal structures of branched-chain amino acid aminotransferase complexed with glutamate and glutarate: True reaction intermediate and double substrate recognition of the enzyme (2003), Biochemistry, 42, 3725-3733.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
space group C2 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-isoleucine + 2-oxoglutarate Rattus norvegicus
-
3-methyl-2-oxopentanoate + L-glutamate
-
r
L-isoleucine + 2-oxoglutarate Escherichia coli
-
3-methyl-2-oxopentanoate + L-glutamate
-
r
L-leucine + 2-oxoglutarate Escherichia coli
-
4-methyl-2-oxopentanoate + L-glutamate
-
r
L-leucine + 2-oxoglutarate Rattus norvegicus key enzyme on the biosynthetic pathway of hydrophobic amino acids 4-methyl-2-oxopentanoate + L-glutamate
-
r
L-valine + 2-oxoglutarate Rattus norvegicus
-
3-methyl-2-oxobutanoate + L-glutamate
-
r
L-valine + 2-oxoglutarate Escherichia coli
-
3-methyl-2-oxobutanoate + L-glutamate
-
r

Organism

Organism UniProt Comment Textmining
Escherichia coli P0AB80
-
-
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-isoleucine + 2-oxoglutarate
-
Rattus norvegicus 3-methyl-2-oxopentanoate + L-glutamate
-
r
L-isoleucine + 2-oxoglutarate
-
Escherichia coli 3-methyl-2-oxopentanoate + L-glutamate
-
r
L-leucine + 2-oxoglutarate
-
Rattus norvegicus 4-methyl-2-oxopentanoate + L-glutamate
-
r
L-leucine + 2-oxoglutarate
-
Escherichia coli 4-methyl-2-oxopentanoate + L-glutamate
-
r
L-leucine + 2-oxoglutarate key enzyme on the biosynthetic pathway of hydrophobic amino acids Rattus norvegicus 4-methyl-2-oxopentanoate + L-glutamate
-
r
L-valine + 2-oxoglutarate
-
Rattus norvegicus 3-methyl-2-oxobutanoate + L-glutamate
-
r
L-valine + 2-oxoglutarate
-
Escherichia coli 3-methyl-2-oxobutanoate + L-glutamate
-
r

Synonyms

Synonyms Comment Organism
BcaT
-
Rattus norvegicus
BcaT
-
Escherichia coli
eBCAT
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Rattus norvegicus
pyridoxal 5'-phosphate
-
Escherichia coli