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Literature summary for 2.6.1.40 extracted from

  • Tamaki, N.; Kaneko, M.; Mizota, C.; Kikugawa, M.; Fujimoto, S.
    Purification, characterization and inhibition of D-3-aminoisobutyrate aminotransferase from the rat liver (1990), Eur. J. Biochem., 189, 39-45.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
6-Azauracil weak, kinetics, not reversible by pyridoxal phosphate Rattus norvegicus
6-azauridine weak Rattus norvegicus
Amino-oxyacetate strong Rattus norvegicus
D-cycloserine
-
Rattus norvegicus
gabaculine
-
Rattus norvegicus
additional information no inhibitor: dihydrothymine, dihydrouracil, N-carbamoyl-beta-alanine, N-carbamoyl-DL-3-aminoisobutyrate; no inhibitor: precursors of beta-alanine or (R)-3-amino-2-methylpropanoate, i.e. orotic acid, uracil, thymine Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.45
-
pyruvate pH 8.8, 37°C Rattus norvegicus
0.81
-
beta-Alanine
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Rattus norvegicus 5737
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
4 * 52000, SDS-PAGE Rattus norvegicus
220000
-
gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-
additional information distribution in rat tissue Rattus norvegicus
-

Storage Stability

Storage Stability Organism
4°C, 0.05 mg protein/ml, in 0.1 M potassium phosphate buffer, pH 7, 1 mM EDTA, 2 mM 2-mercaptoethanol, about 50% loss of activity within a few days, 80% loss within 1 week Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-3-amino-2-methylpropanoate + glyoxylate
-
Rattus norvegicus 2-methyl-3-oxopropanoate + glycine
-
?
(R)-3-amino-2-methylpropanoate + oxaloacetate
-
Rattus norvegicus 2-methyl-3-oxopropanoate + L-aspartate
-
?
(R)-3-amino-2-methylpropanoate + pyruvate
-
Rattus norvegicus 2-methyl-3-oxopropanoate + L-alanine
-
?
5-aminolevulinic acid + pyruvate
-
Rattus norvegicus 5-oxolevulinic acid + L-alanine
-
?
beta-alanine + pyruvate
-
Rattus norvegicus malonic semialdehyde + L-alanine
-
?
additional information overview Rattus norvegicus ?
-
?
additional information no substrate: 2-oxoglutarate Rattus norvegicus ?
-
?
additional information no substrate: phenylpyruvate Rattus norvegicus ?
-
?
NG,NG'-dimethyl-(S)-arginine + pyruvate
-
Rattus norvegicus ? + L-alanine
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 52000, SDS-PAGE Rattus norvegicus
tetramer cross-linking experiments: tetramer composed of two dimers Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
pI: 6.7 Rattus norvegicus
9.5
-
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Rattus norvegicus