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Literature summary for 2.6.1.36 extracted from

  • Liras, P.; Demain, A.L.
    Enzymology of beta-lactam compounds with cephem structure produced by actinomycete (2009), Methods Enzymol., 458, 401-429.
    View publication on PubMed

Application

Application Comment Organism
biotechnology production of beta-lactam antibiotics Actinomyces sp.

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48810
-
lysine epsilon-aminotransferase is a 450 amino acid protein Actinomyces sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lysine + 2-oxoglutarate Actinomyces sp.
-
2-aminoadipate 6-semialdehyde + L-glutamate
-
?

Organism

Organism UniProt Comment Textmining
Actinomyces sp.
-
-
-

Purification (Commentary)

Purification (Comment) Organism
lysine epsilon-aminotransferase is partially purified from a high-producing strain of Streptomyces lactamdurans Actinomyces sp.

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
lysine epsilon-aminotransferase activity peaks earlier than cephamycin formation in producer strains and an increase in lat copy number results in a 2- to 5fold increase of cephamycin formation, suggesting that formation of alpha-aminoadipic acid is a limiting step for cephamycin formation Actinomyces sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lysine + 2-oxoglutarate
-
Actinomyces sp. 2-aminoadipate 6-semialdehyde + L-glutamate
-
?

Synonyms

Synonyms Comment Organism
LAT
-
Actinomyces sp.
lysine epsilon-aminotransferase
-
Actinomyces sp.

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate lysine epsilon-aminotransferase requires pyridoxal 5'-phosphate, which has a binding site at Lys300 of the Nocardia lactamdurans LAT protein as cofactor Actinomyces sp.