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Literature summary for 2.6.1.36 extracted from

  • Hammer, T.; Bode, R.
    Purification and characterization of an inducible L-lysine: 2-oxoglutarate 6-aminotransferase from Candida utilis (1992), J. Basic Microbiol., 32, 21-27.
    View publication on PubMed
Search for more literature for 2.6.1.36

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5
-
 L-lysine pH 8.5, 37°C Cyberlindnera jadinii
3.8
-
 2-oxoglutarate
-
 Cyberlindnera jadinii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
40000
-
 2 * 40000, SDS-PAGE Cyberlindnera jadinii
83000
-
 gel filtration Cyberlindnera jadinii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lysine + 2-oxoglutarate Cyberlindnera jadinii
-
 2-aminoadipate 6-semialdehyde + L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Cyberlindnera jadinii
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Cyberlindnera jadinii

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Cyberlindnera jadinii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lysine + 2-oxoadipate 7% of the activity with 2-oxoglutarate Cyberlindnera jadinii 2-aminoadipate 6-semialdehyde + L-homoglutarate
-
 ?
L-lysine + 2-oxoglutarate
-
 Cyberlindnera jadinii 2-aminoadipate 6-semialdehyde + L-glutamate
-
 ?
L-lysine + oxaloacetate 38% of the activity with 2-oxoglutarate Cyberlindnera jadinii 2-aminoadipate 6-semialdehyde + L-aspartate
-
 ?
L-lysine + pyruvate 19% of the activity with 2-oxoglutarate Cyberlindnera jadinii 2-aminoadipate 6-semialdehyde + L-alanine
-
 ?
L-thialysine + 2-oxoglutarate 13% of the activity with L-lysine Cyberlindnera jadinii ? + L-glutamate
-
 ?
S-(2-aminoethyl)-L-cysteine + 2-oxoglutarate 16% of the activity with L-lysine Cyberlindnera jadinii ? + L-glutamate
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 40000, SDS-PAGE Cyberlindnera jadinii

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Cyberlindnera jadinii
40
-
-
 Cyberlindnera jadinii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.5
-
-
 Cyberlindnera jadinii

pH Range

pH Minimum pH Maximum Comment Organism
7.2 10.2 about 50% of maximum activity at pH 7.2 and pH 10.2 Cyberlindnera jadinii

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate 2 mol of pyridoxal 5'-phosphate per mol of holoenzyme Cyberlindnera jadinii
pyridoxal 5'-phosphate Km 0.015 mM Cyberlindnera jadinii