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Literature summary for 2.6.1.30 extracted from

  • Ayling, J.E.; Snell, E.E.
    Relation of structure to activity of pyridoxal analogs as substrates for pyridoxamine pyruvate transaminase (1968), Biochemistry, 7, 1626-1636.
    View publication on PubMed
Search for more literature for 2.6.1.30

Inhibitors

Inhibitors Comment Organism Structure
3-Deoxypyridoxal inhibits pyridoxamine formation from pyridoxal + alanine Pseudomonas sp.
4-Nitrosalicylaldehyde inhibits pyridoxamine formation from pyridoxal + alanine Pseudomonas sp.
N-Methylpyridoxal inhibits pyridoxamine formation from pyridoxal + alanine Pseudomonas sp.
O-Methylpyridoxal inhibits pyridoxamine formation from pyridoxal + alanine Pseudomonas sp.
Pyridine-4-aldehyde inhibits pyridoxamine formation from pyridoxal + alanine Pseudomonas sp.

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics Pseudomonas sp.
0.009
-
 5-Deoxypyridoxal pH 8.9, 25°C Pseudomonas sp.
0.012
-
 pyridoxal pH 8.9, 25°C Pseudomonas sp.
0.013
-
 pyridoxamine pH 8.9, 25°C Pseudomonas sp.
0.014
-
 5-Deoxypyridoxamine pH 8.9, 25°C Pseudomonas sp.
0.16
-
 2-Norpyridoxamine pH 8.9, 25°C Pseudomonas sp.
0.35
-
 pyruvate with 3-hydroxy-4-aminomethylpyridine, pH 8.9, 25°C Pseudomonas sp.
0.35
-
 pyridoxamine with 3-hydroxy-4-aminomethylpyridine, pH 8.9, 25°C Pseudomonas sp.
0.4
-
 pyruvate with omega-methylpyridoxamine, pH 8.9, 25°C Pseudomonas sp.
0.42
-
 pyruvate with 5-deoxypyridoxamine, pH 8.9, 25°C Pseudomonas sp.
0.52
-
 pyruvate with 2-norpyridoxamine, pH 8.9, 25°C Pseudomonas sp.
0.58
-
 L-alanine with omega-methylpyridoxal, pH 8.9, 25°C Pseudomonas sp.
0.59
-
 2-norpyridoxal pH 8.9, 25°C Pseudomonas sp.
0.89
-
 3-hydroxypyridine-4-aldehyde pH 8.9, 25°C Pseudomonas sp.
1.3
-
 omega-methylpyridoxal pH 8.9, 25°C Pseudomonas sp.
1.6
-
 L-alanine with pyridoxal, pH 8.9, 25°C Pseudomonas sp.
1.9
-
 L-alanine with 5-deoxypyridoxal, pH 8.9, 25°C Pseudomonas sp.
2.7
-
 L-alanine with 2-norpyridoxal, pH 8.9, 25°C Pseudomonas sp.
7.4
-
 pyruvate with 3-hydroxy-4-aminomethylpyridine, pH 8.9, 25°C Pseudomonas sp.
64.5
-
 L-alanine with 3-hydroxypyridine-4-aldehyde, pH 8.9, 25°C Pseudomonas sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyridoxamine + pyruvate Pseudomonas sp.
-
 pyridoxal + L-alanine
-
 r

Organism

Organism UniProt Comment Textmining
Pseudomonas sp.
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-norpyridoxal + L-alanine
-
 Pseudomonas sp. 2-norpyridoxamine + pyruvate
-
 r
3-hydroxypyridine-4-aldehyde + L-alanine
-
 Pseudomonas sp. 3-hydroxy-4-aminomethylpyridine + pyruvate
-
 r
5-deoxypyridoxal + L-alanine
-
 Pseudomonas sp. 5-deoxypyridoxamine + pyruvate
-
 r
additional information not active with: 3-deoxypyridoxal, pyridine-4-aldehyde, O-methylpyridoxal, 4-nitrosalicylaldehyde Pseudomonas sp. ?
-
 ?
omega-methylpyridoxal + L-alanine i.e. 3-hydroxy-5-hydroxymethyl-2-ethylpyridine-4-carboxaldehyde Pseudomonas sp. omega-methylpyridoxamine + pyruvate
-
 r
pyridoxamine + pyruvate
-
 Pseudomonas sp. pyridoxal + L-alanine
-
 r