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Literature summary for 2.6.1.19 extracted from

  • Maguire, S.E.; Rhoades, S.; Chen, W.F.; Sengupta, A.; Yue, Z.; Lim, J.C.; Mitchell, C.H.; Weljie, A.M.; Sehgal, A.
    Independent effects of gamma-aminobutyric acid transaminase (GABAT) on metabolic and sleep homeostasis (2015), J. Biol. Chem., 290, 20407-20416.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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General Information

General Information Comment Organism
physiological function loss of GABA transaminase increases sleep, and affects metabolism such that flies lacking GABA transaminase fail to survive on carbohydrate media. GABA degradation product glutamate, rather than succinic semialdehyde, accounts for the metabolic phenotype of the mutants. Inhibition of GABA transaminase affects energetic pathways. Mutants display a general disruption in bioenergetics. The effects of GABA transaminase on sleep do not depend upon glutamate, indicating that GABAT regulates metabolic and sleep homeostasis through independent mechanisms Drosophila melanogaster