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Literature summary for 2.6.1.19 extracted from

  • Tao, Y.H.; Xu, H.B.; Yang, X.L.
    Inactivation of GABA transaminase by 3-chloro-1-(4-hydroxyphenyl)propan-1-one (2009), Bioorg. Med. Chem. Lett., 19, 731-734.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(Z)-4-amino-2-butenoic acid
-
Homo sapiens
3-chloro-1-(4-hydroxyphenyl)propan-1-one irreversible and potent inhibitor, about 30% residual activity at 0.06 mM, 2-oxoglutarate prevents the enzyme from inactivation Homo sapiens
4-hydroxybenzaldehyde competitive inhibitor of GABA transaminase Homo sapiens
vigabatrin
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-aminobutanoate + 2-oxoglutarate
-
Homo sapiens 4-oxobutanoate + L-glutamate
-
?

Synonyms

Synonyms Comment Organism
GABA transaminase
-
Homo sapiens
GABA-T
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00399
-
-
Homo sapiens 3-chloro-1-(4-hydroxyphenyl)propan-1-one
0.0165
-
-
Homo sapiens 4-hydroxybenzaldehyde