Literature summary for 2.6.1.19 extracted from

Tao, Y.H.; Yuan, Z.; Tang, X.Q.; Xu, H.B.; Yang, X.L.
Inhibition of GABA shunt enzymes activity by 4-hydroxybenzaldehyde derivatives (2006), Bioorg. Med. Chem. Lett., 16, 592-595.

Search for more literature for 2.6.1.19

Inhibitors

Inhibitors	Comment	Organism	Structure
4-hydroxybenzaldehyde	IC50: 0.0165 mM, competitive inhibition	Homo sapiens
4-hydroxybenzylamine	IC50: 0.0154 mM, competitive inhibition	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-aminobutanoate + 2-oxoglutarate	-	Homo sapiens	4-oxobutanoate + L-glutamate	-	?

Synonyms

Synonyms	Comment	Organism
GABA transaminase	-	Homo sapiens
GABA-T	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0154	-	IC50: 0.0154 mM, competitive inhibition	Homo sapiens	4-hydroxybenzylamine
0.0165	-	IC50: 0.0165 mM, competitive inhibition	Homo sapiens	4-hydroxybenzaldehyde

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Release 2023.1 (January 2023)