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Literature summary for 2.6.1.19 extracted from

  • Voellmy, R.; Leisinger, T.
    Role of 4-aminobutyrate aminotransferase in the arginine metabolism of Pseudomonas aeruginosa (1976), J. Bacteriol., 128, 722-729.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.75
-
2-oxoglutarate
-
Pseudomonas aeruginosa
1.2
-
4-aminobutanoate
-
Pseudomonas aeruginosa
2.5
-
putrescine
-
Pseudomonas aeruginosa
2.9
-
L-ornithine
-
Pseudomonas aeruginosa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
200000
-
sucrose density gradient centrifugation Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Pseudomonas aeruginosa enzyme is induced in cells grown on 4-guanidinobutyrate, 4-aminobutyrate, or putrescine as the only carbon and nitrogen source. GABAT functions in the biosynthesis of arginine by converting N2-acetyl-L-glutamate 5-semialdehyde to N2-acetyl-L-ornithine as well as in catabolic reactions during growth on putrescine or 4-guanidinobutyrate but not during growth on arginine ?
-
?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Pseudomonas aeruginosa

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.85
-
-
Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-aminobutanoate + 2-oxoglutarate best substrate at pH 9.5 as well as at pH 8.5 Pseudomonas aeruginosa 4-oxobutanoate + L-glutamate
-
?
cadaverine + 2-oxoglutarate
-
Pseudomonas aeruginosa L-glutamate + 5-aminopentanal
-
?
L-lysine + 2-oxoglutarate
-
Pseudomonas aeruginosa L-glutamate + (S)-2-amino-6-oxohexanoate i.e. L-2-aminoadipate-6-semialdehyde ?
L-ornithine + 2-oxoglutarate
-
Pseudomonas aeruginosa L-glutamate + (S)-2-amino-5-oxopentanoate i.e. L-glutamate-gamma-semialdehyde ?
additional information enzyme is induced in cells grown on 4-guanidinobutyrate, 4-aminobutyrate, or putrescine as the only carbon and nitrogen source. GABAT functions in the biosynthesis of arginine by converting N2-acetyl-L-glutamate 5-semialdehyde to N2-acetyl-L-ornithine as well as in catabolic reactions during growth on putrescine or 4-guanidinobutyrate but not during growth on arginine Pseudomonas aeruginosa ?
-
?
putrescine + 2-oxoglutarate
-
Pseudomonas aeruginosa L-glutamate + 4-aminobutanal
-
?

Synonyms

Synonyms Comment Organism
GABAT
-
Pseudomonas aeruginosa