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Literature summary for 2.6.1.19 extracted from

  • Yuan, H.; Silverman, R.B.
    New substrates and inhibitors of gamma-aminobutyric acid aminotransferase containing bioisosteres of the carboxylic acid group: Design, synthesis, and biological activity (2005), Bioorg. Med. Chem., 14, 1331-1338.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1H-tetrazole-5-(alpha-vinyl-propanamine)
-
Sus scrofa
4-aminohex-5-enoic acid
-
Sus scrofa
tetrazole-5-(alpha-vinyl-propanamine)
-
Sus scrofa
vigabatrin
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3
-
1H-tetrazole-5-ethanamine pH 8.5 Sus scrofa
2.3
-
tetrazole-5-ethanamine at 25°C in 50 mM potassium diphosphate buffer, pH 8.5, containing 2 mM beta-mercaptoethanol Sus scrofa
2.4
-
4-aminobutanoate pH 8.5 Sus scrofa
2.4
-
1H-tetrazole-5-propanamine pH 8.5 Sus scrofa
2.4
-
4-aminobutanoate at 25°C in 50 mM potassium diphosphate buffer, pH 8.5, containing 2 mM beta-mercaptoethanol Sus scrofa
2.4
-
tetrazole-5-propanamine at 25°C in 50 mM potassium diphosphate buffer, pH 8.5, containing 2 mM beta-mercaptoethanol Sus scrofa
8
-
1H-tetrazole-5-butanamine pH 8.5 Sus scrofa
8
-
tetrazole-5-butanamine at 25°C in 50 mM potassium diphosphate buffer, pH 8.5, containing 2 mM beta-mercaptoethanol Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1H-tetrazole-5-butanamine + 2-oxoglutarate
-
Sus scrofa (1H-tetrazol-5-yl)-butyraldehyde + L-glutamate
-
?
1H-tetrazole-5-ethanamine + 2-oxoglutarate
-
Sus scrofa (1H-tetrazol-5-yl)-acetaldehyd + L-glutamate
-
?
1H-tetrazole-5-propanamine + 2-oxoglutarate
-
Sus scrofa (1H-tetrazol-5-yl)-propionaldehyde + L-glutamate
-
?
4-aminobutanoate + 2-oxoglutarate
-
Sus scrofa 4-oxobutanoate + L-glutamate
-
?
tetrazole-5-butanamine + 2-oxoglutarate
-
Sus scrofa ?
-
?
tetrazole-5-ethanamine + 2-oxoglutarate
-
Sus scrofa ?
-
?
tetrazole-5-propanamine + 2-oxoglutarate
-
Sus scrofa ?
-
?

Synonyms

Synonyms Comment Organism
GABA-AT
-
Sus scrofa
gamma-aminobutyric acid aminotransferase
-
Sus scrofa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.26
-
1H-tetrazole-5-ethanamine pH 8.5 Sus scrofa
0.265
-
tetrazole-5-ethanamine at 25°C in 50 mM potassium diphosphate buffer, pH 8.5, containing 2 mM beta-mercaptoethanol Sus scrofa
0.477
-
tetrazole-5-propanamine at 25°C in 50 mM potassium diphosphate buffer, pH 8.5, containing 2 mM beta-mercaptoethanol Sus scrofa
0.48
-
1H-tetrazole-5-propanamine pH 8.5 Sus scrofa
0.69
-
1H-tetrazole-5-butanamine pH 8.5 Sus scrofa
0.693
-
tetrazole-5-butanamine at 25°C in 50 mM potassium diphosphate buffer, pH 8.5, containing 2 mM beta-mercaptoethanol Sus scrofa
0.81
-
4-aminobutanoate pH 8.5 Sus scrofa
0.817
-
4-aminobutanoate at 25°C in 50 mM potassium diphosphate buffer, pH 8.5, containing 2 mM beta-mercaptoethanol Sus scrofa

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate dependent Sus scrofa

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.6
-
4-aminohex-5-enoic acid
-
Sus scrofa
2.6
-
vigabatrin pH 8.5 Sus scrofa
5.6
-
tetrazole-5-(alpha-vinyl-propanamine)
-
Sus scrofa
5.6
-
1H-tetrazole-5-(alpha-vinyl-propanamine) pH 8.5 Sus scrofa