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Literature summary for 2.6.1.19 extracted from

  • Qiu, J.; Pingsterhaus, J.M.; Silverman, R.B.
    Inhibition and substrate activity of conformationally rigid vigabatrin analogues with gamma-aminobutyric acid aminotransferase (1999), J. Med. Chem., 42, 4725-4728.
    View publication on PubMed
Search for more literature for 2.6.1.19

Inhibitors

Inhibitors Comment Organism Structure
(1R,4S)-4-amino-2-cyclopentene-1-carboxylic acid analogue of 4-aminobutanoate, vigabatrin Sus scrofa
(1S,4R)-4-amino-2-cyclopentene-1-carboxylic acid analogue of 4-aminobutanoate, vigabatrin Sus scrofa
(4R)-4-amino-1-cyclopentene-1-carboxylic acid analogue of 4-aminobutanoate, vigabatrin Sus scrofa
(4S)-4-amino-1-cyclopentene-1-carboxylic acid analogue of 4-aminobutanoate, vigabatrin Sus scrofa
DL-3-amino-1-cyclopentene-1-carboxylic acid analogue of 4-aminobutanoate, vigabatrin Sus scrofa
DL-trans-4-amino-2-cyclopentene-1-carboxylic acid analogue of 4-aminobutanoate, vigabatrin Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
 (4R)-4-amino-1-cyclopentene-1-carboxylic acid
-
 Sus scrofa
1.6
-
 (4R)-4-amino-1-cyclopentene-1-carboxylic acid
-
 Sus scrofa
2.3
-
 DL-3-amino-1-cyclopentene-1-carboxylic acid
-
 Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(1R,4S)-4-amino-2-cyclopentene-1-carboxylic acid + 2-oxoglutarate analogue of 4-aminobutanoate, vigabatrin Sus scrofa ? + L-glutamate
-
 ?
(4R)-4-amino-1-cyclopentene-1-carboxylic acid + 2-oxoglutarate analogue of 4-aminobutanoate, vigabatrin Sus scrofa 4-oxo-1-cyclopentene1-carboxylic acid + L-glutamate
-
 ?
DL-3-amino-1-cyclopentene-1-carboxylic acid + 2-oxoglutarate analogue of 4-aminobutanoate, vigabatrin Sus scrofa 3-oxo-1-cyclopentene-1-carboxylic acid + L-glutamate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.052
-
 (1R,4S)-4-amino-2-cyclopentene-1-carboxylic acid
-
 Sus scrofa
0.6
-
 DL-3-amino-1-cyclopentene-1-carboxylic acid
-
 Sus scrofa
1.2
-
 (4R)-4-amino-1-cyclopentene-1-carboxylic acid
-
 Sus scrofa
2.7
-
 (1S,4R)-4-amino-2-cyclopentene-1-carboxylic acid
-
 Sus scrofa
38
-
 DL-trans-4-amino-2-cyclopentene-1-carboxylic acid
-
 Sus scrofa
72
-
 (4S)-4-amino-1-cyclopentene-1-carboxylic acid
-
 Sus scrofa