Any feedback?
Literature summary for 2.6.1.18 extracted from
- omega-Transaminase-catalyzed kinetic resolution of chiral amines using l-threonine as an amino acceptor precursor (2012), Green Chem., 14, 2137-2140.
No PubMed abstract available
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus terreus | - |
enantioselectivity of the omega-TA from Aspergillus terreus is opposite to that from Ochrobactrum anthropi | - |
| Brucella anthropi | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-phenylethanamine + 2-oxobutyrate | enantioselectivity of the omega-TA from Aspergillus terreus is opposite to that from Ochrobactrum anthropi, D-homoalanine of more than 99% enantiomeric excess is formed in this coupled reaction | Aspergillus terreus | acetophenone + D-homoalanine | - |
? |  |
| 1-phenylethanamine + 2-oxobutyrate | - |
Brucella anthropi | acetophenone + L-homoalanine | - |
? | |
| 1-phenylethanamine + propanal | 94% relative activity toward propanal compared to pyruvate. Propanal is an inefficient amino acceptor for the kinetic resolution: Enantiomeric excess of (R)-alpha-methylbenzylamine reaches more than 99% with pyruvate at 3 h, whereas enantiomeric excess is only 57% with propanal even after the reaction for 24 h | Brucella anthropi | ? | - |
? | |
| 1-phenylethanamine + pyruvate | relative activity toward pyruvate: 100% | Aspergillus terreus | acetophenone + alanine | - |
? | |
| 1-phenylethanamine + pyruvate | relative activity toward pyruvate: 100% | Brucella anthropi | acetophenone + alanine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| omega-TA | - |
Aspergillus terreus |
| omega-transaminase | - |
Aspergillus terreus |
| omega-transaminase | - |
Brucella anthropi |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Aspergillus terreus |
| 37 | - |
assay at | Brucella anthropi |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Aspergillus terreus |
| 7.5 | - |
assay at | Brucella anthropi |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Aspergillus terreus | |
| pyridoxal 5'-phosphate | - |
Brucella anthropi | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
