BRENDA - Enzyme Database show
show all sequences of 2.6.1.18

omega-Amino acid:pyruvate transaminase from Alcaligenes denitrificans Y2k-2: a new catalyst for kinetic resolution of beta-amino acids and amines

Yun, H.; Lim, S.; Cho, B.K.; Kim, B.G.; Appl. Environ. Microbiol. 70, 2529-2534 (2004)

Data extracted from this reference:

Application
Application
Commentary
Organism
additional information
the enzyme can be utilized as a catalyst for kinetic resolution of beta-amino acids and amines
Achromobacter denitrificans
synthesis
enzymatic synthesis of enantiomerically pure D-beta-amino-n-butyric acid from racemic beta-amino-n-butyric acid
Achromobacter denitrificans
Cloned(Commentary)
Commentary
Organism
gene aptA, DNA and amino acid sequence determination and analysis, functional expression of the His-tagged enzyme in Escherichia coli strain BL21
Achromobacter denitrificans
Inhibitors
Inhibitors
Commentary
Organism
Structure
3-amino-2,3-dihydrobenzoic acid
i.e. gabaculine, strong inhibition
Achromobacter denitrificans
aminooxyacetic acid
strong inhibition
Achromobacter denitrificans
hydroxylamine
strong inhibition
Achromobacter denitrificans
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
kinetics
Achromobacter denitrificans
11
-
pyruvate
recombinant enzyme
Achromobacter denitrificans
56
-
L-beta-amino-n-butyric acid
recombinant enzyme
Achromobacter denitrificans
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-beta-amino-n-butyric acid + pyruvate
Achromobacter denitrificans
-
3-oxo-n-butyric acid + alanine
-
-
?
L-beta-amino-n-butyric acid + pyruvate
Achromobacter denitrificans Y2k-2
-
3-oxo-n-butyric acid + alanine
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Achromobacter denitrificans
Q7WWK8
gene aptA
-
Achromobacter denitrificans Y2k-2
Q7WWK8
gene aptA
-
Purification (Commentary)
Commentary
Organism
recombinant His-tagged enzyme from Escherichia coli strain BL21
Achromobacter denitrificans
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
77.2
-
purified recombinant enzyme
Achromobacter denitrificans
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(R,S)-1,2-dimethylpropylamine + pyruvate
7.5% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans
3-methyl-2-oxobutane + alanine
-
-
-
?
(R,S)-1,2-dimethylpropylamine + pyruvate
7.5% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans Y2k-2
3-methyl-2-oxobutane + alanine
-
-
-
?
(R,S)-1,5-dimethylhexylamine + pyruvate
8.3% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans
6-methyl-2-oxoheptane + alanine
-
-
-
?
(R,S)-1,5-dimethylhexylamine + pyruvate
8.3% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans Y2k-2
6-methyl-2-oxoheptane + alanine
-
-
-
?
(R,S)-2-aminoheptane + pyruvate
9.1% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans
2-oxoheptane + alanine
-
-
-
?
(R,S)-2-aminoheptane + pyruvate
9.1% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans Y2k-2
2-oxoheptane + alanine
-
-
-
?
(R,S)-sec-butylamine + pyruvate
7.3% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans
? + alanine
-
-
-
?
(S)-alpha-methylbenzylamine + pyruvate
14% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans
acetophenone + alanine
-
-
-
?
beta-alanine + pyruvate
10% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans
oxaloacetate + alanine
-
-
-
?
butyraldehyde + (S)-alpha-methylbenzylamine
118% of activity with pyruvate
657597
Achromobacter denitrificans
? + acetophenone
-
-
-
?
glyoxylate + (S)-alpha-methylbenzylamine
13% of activity with pyruvate
657597
Achromobacter denitrificans
glycine + acetophenone
-
-
-
?
L-beta-amino-n-butyric acid + pyruvate
-
657597
Achromobacter denitrificans
3-oxo-n-butyric acid + alanine
-
-
-
?
L-beta-amino-n-butyric acid + pyruvate
-
657597
Achromobacter denitrificans Y2k-2
3-oxo-n-butyric acid + alanine
-
-
-
?
L-beta-amino-n-butyric acid + pyruvate
high activity, highly stereoselective enzyme
657597
Achromobacter denitrificans
3-oxobutyrate + alanine
-
-
-
?
L-beta-homoleucine + pyruvate
2.6% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans
5-methyl-3-oxohexanoate + alanine
-
-
-
?
L-beta-leucine + pyruvate
4.3% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans
4-methyl-3-oxopentanoate + alanine
-
-
-
?
additional information
substrate specificity, (R,S)-alpha-ethylbenzylamine, L-beta-homoisoleucin, L-3-amino-3-phenylpropanoic acid, (R,S)-1,2-dimethylbutylamine, oxalacetate, alpha-ketoglutarate, and ethylacetoacetate are no substrates
657597
Achromobacter denitrificans
?
-
-
-
-
additional information
substrate specificity, (R,S)-alpha-ethylbenzylamine, L-beta-homoisoleucin, L-3-amino-3-phenylpropanoic acid, (R,S)-1,2-dimethylbutylamine, oxalacetate, alpha-ketoglutarate, and ethylacetoacetate are no substrates
657597
Achromobacter denitrificans Y2k-2
?
-
-
-
-
propion aldehyde + (S)-alpha-methylbenzylamine
105% of activity with pyruvate
657597
Achromobacter denitrificans
? + acetophenone
-
-
-
?
pyruvic aldehyde + (S)-alpha-methylbenzylamine
5% of activity with pyruvate
657597
Achromobacter denitrificans
? + acetophenone
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Achromobacter denitrificans
Application (protein specific)
Application
Commentary
Organism
additional information
the enzyme can be utilized as a catalyst for kinetic resolution of beta-amino acids and amines
Achromobacter denitrificans
synthesis
enzymatic synthesis of enantiomerically pure D-beta-amino-n-butyric acid from racemic beta-amino-n-butyric acid
Achromobacter denitrificans
Cloned(Commentary) (protein specific)
Commentary
Organism
gene aptA, DNA and amino acid sequence determination and analysis, functional expression of the His-tagged enzyme in Escherichia coli strain BL21
Achromobacter denitrificans
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
pyridoxal 5'-phosphate
-
Achromobacter denitrificans
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
3-amino-2,3-dihydrobenzoic acid
i.e. gabaculine, strong inhibition
Achromobacter denitrificans
aminooxyacetic acid
strong inhibition
Achromobacter denitrificans
hydroxylamine
strong inhibition
Achromobacter denitrificans
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
kinetics
Achromobacter denitrificans
11
-
pyruvate
recombinant enzyme
Achromobacter denitrificans
56
-
L-beta-amino-n-butyric acid
recombinant enzyme
Achromobacter denitrificans
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
L-beta-amino-n-butyric acid + pyruvate
Achromobacter denitrificans
-
3-oxo-n-butyric acid + alanine
-
-
?
L-beta-amino-n-butyric acid + pyruvate
Achromobacter denitrificans Y2k-2
-
3-oxo-n-butyric acid + alanine
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
recombinant His-tagged enzyme from Escherichia coli strain BL21
Achromobacter denitrificans
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
77.2
-
purified recombinant enzyme
Achromobacter denitrificans
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
(R,S)-1,2-dimethylpropylamine + pyruvate
7.5% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans
3-methyl-2-oxobutane + alanine
-
-
-
?
(R,S)-1,2-dimethylpropylamine + pyruvate
7.5% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans Y2k-2
3-methyl-2-oxobutane + alanine
-
-
-
?
(R,S)-1,5-dimethylhexylamine + pyruvate
8.3% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans
6-methyl-2-oxoheptane + alanine
-
-
-
?
(R,S)-1,5-dimethylhexylamine + pyruvate
8.3% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans Y2k-2
6-methyl-2-oxoheptane + alanine
-
-
-
?
(R,S)-2-aminoheptane + pyruvate
9.1% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans
2-oxoheptane + alanine
-
-
-
?
(R,S)-2-aminoheptane + pyruvate
9.1% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans Y2k-2
2-oxoheptane + alanine
-
-
-
?
(R,S)-sec-butylamine + pyruvate
7.3% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans
? + alanine
-
-
-
?
(S)-alpha-methylbenzylamine + pyruvate
14% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans
acetophenone + alanine
-
-
-
?
beta-alanine + pyruvate
10% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans
oxaloacetate + alanine
-
-
-
?
butyraldehyde + (S)-alpha-methylbenzylamine
118% of activity with pyruvate
657597
Achromobacter denitrificans
? + acetophenone
-
-
-
?
glyoxylate + (S)-alpha-methylbenzylamine
13% of activity with pyruvate
657597
Achromobacter denitrificans
glycine + acetophenone
-
-
-
?
L-beta-amino-n-butyric acid + pyruvate
-
657597
Achromobacter denitrificans
3-oxo-n-butyric acid + alanine
-
-
-
?
L-beta-amino-n-butyric acid + pyruvate
-
657597
Achromobacter denitrificans Y2k-2
3-oxo-n-butyric acid + alanine
-
-
-
?
L-beta-amino-n-butyric acid + pyruvate
high activity, highly stereoselective enzyme
657597
Achromobacter denitrificans
3-oxobutyrate + alanine
-
-
-
?
L-beta-homoleucine + pyruvate
2.6% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans
5-methyl-3-oxohexanoate + alanine
-
-
-
?
L-beta-leucine + pyruvate
4.3% of activity with L-beta-amino-n-butyric acid
657597
Achromobacter denitrificans
4-methyl-3-oxopentanoate + alanine
-
-
-
?
additional information
substrate specificity, (R,S)-alpha-ethylbenzylamine, L-beta-homoisoleucin, L-3-amino-3-phenylpropanoic acid, (R,S)-1,2-dimethylbutylamine, oxalacetate, alpha-ketoglutarate, and ethylacetoacetate are no substrates
657597
Achromobacter denitrificans
?
-
-
-
-
additional information
substrate specificity, (R,S)-alpha-ethylbenzylamine, L-beta-homoisoleucin, L-3-amino-3-phenylpropanoic acid, (R,S)-1,2-dimethylbutylamine, oxalacetate, alpha-ketoglutarate, and ethylacetoacetate are no substrates
657597
Achromobacter denitrificans Y2k-2
?
-
-
-
-
propion aldehyde + (S)-alpha-methylbenzylamine
105% of activity with pyruvate
657597
Achromobacter denitrificans
? + acetophenone
-
-
-
?
pyruvic aldehyde + (S)-alpha-methylbenzylamine
5% of activity with pyruvate
657597
Achromobacter denitrificans
? + acetophenone
-
-
-
?
Other publictions for EC 2.6.1.18
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
737507
Wilding
A beta-alanine batabolism path ...
Pseudomonas sp., Pseudomonas sp. AAC
Appl. Environ. Microbiol.
82
3846-3856
2016
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1
1
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2
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18
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1
1
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18
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-
738138
Mathew
Biochemical characterization o ...
Sphaerobacter thermophilus, Sphaerobacter thermophilus DSM 20745
Enzyme Microb. Technol.
87-88
52-60
2016
-
-
1
-
-
-
-
-
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1
2
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1
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13
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1
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1
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13
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1
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-
737842
Fuchs
Synthesis of (R)- or (S)-valin ...
Arabidopsis thaliana, Bacillus megaterium, Fusarium graminearum
Bioorg. Med. Chem.
22
5558-5562
2014
-
3
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3
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3
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3
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737864
Han
Metabolically driven equilibri ...
Ochrobactrum anthropi
Biosci. Biotechnol. Biochem.
78
1788-1790
2014
-
1
1
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1
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1
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1
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721915
Cardenas-Fernandez
Immobilization of Escherichia ...
Escherichia coli
Biotechnol. Prog.
28
693-698
2012
-
1
1
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1
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2
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1
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1
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1
1
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2
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1
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1
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-
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-
-
-
-
-
-
722376
Malik
-
omega-Transaminase-catalyzed k ...
Aspergillus terreus, Ochrobactrum anthropi
Green Chem.
14
2137-2140
2012
-
-
-
-
-
-
-
-
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2
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5
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2
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2
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2
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2
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5
-
2
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2
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-
723317
Seo
Deracemization of unnatural am ...
Vibrio fluvialis
Org. Biomol. Chem.
10
2482-2485
2012
-
1
1
-
-
-
1
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-
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1
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1
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1
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1
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1
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1
1
1
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1
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1
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1
-
1
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-
-
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721893
Bea
-
Asymmetric synthesis of (R)-3- ...
Vibrio fluvialis
Biotechnol. Bioprocess Eng.
16
291-296
2011
-
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1
-
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1
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-
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
-
-
-
-
-
-
-
-
-
684253
Hoehne
-
A protection strategy substant ...
Achromobacter denitrificans, Vibrio fluvialis
Adv. Synth. Catal.
350
807-812
2008
-
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2
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12
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12
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-
-
-
-
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-
671123
Sayer
Crystallization and preliminar ...
Chromobacterium violaceum
Acta Crystallogr. Sect. F
63
117-119
2007
-
-
1
1
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-
-
-
-
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1
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2
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1
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1
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1
1
1
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1
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1
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684207
Sayer
Crystallization and preliminar ...
Chromobacterium violaceum
Acta Crystallogr. Sect. F
F63
117-119
2007
-
-
1
1
-
-
-
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