Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(N-(succinylamino))-6-hydrazinoheptane-1,7-dioic acid | very potent slow-binding inhibitor, synthesis | Escherichia coli | |
2-(N-Carbobenzoxy-amino)-6-hydrazinoheptane-1,7-dioic acid | very potent slow-binding inhibitor, synthesis | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.18 | - |
N-Succinyl-2-amino-6-oxoheptanedioate | 30°C, pH 8.0 | Escherichia coli | |
1.21 | - |
L-glutamate | 30°C, pH 8.0 | Escherichia coli |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
39900 | - |
2 * 39900, SDS-PAGE, MALDI-TOF mass spectra | Escherichia coli |
82000 | - |
gel filtration | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate | Escherichia coli | a key enzyme in the bacterial pathway to L-lysine | N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | structural requirements for substrate recognition | Escherichia coli | ? | - |
? | |
N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate | i.e. N-succinyl-alpha-amino-epsilon-ketopimelic acid | Escherichia coli | N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate | - |
r | |
N-succinyl-2-amino-6-oxoheptanedioate + L-glutamate | a key enzyme in the bacterial pathway to L-lysine | Escherichia coli | N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 39900, SDS-PAGE, MALDI-TOF mass spectra | Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | - |
Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000004 | - |
2-(N-(succinylamino))-6-hydrazinoheptane-1,7-dioic acid | 30°C, pH 8.0 | Escherichia coli | |
0.000054 | - |
2-(N-Carbobenzoxy-amino)-6-hydrazinoheptane-1,7-dioic acid | 30°C, pH 8.0 | Escherichia coli |