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Literature summary for 2.6.1.16 extracted from
- Naringenin derivatives as glucosamine-6-phosphate synthase inhibitors synthesis, antioxidants, antimicrobial, preservative efficacy, molecular docking and in silico ADMET analysis (2020), BMC Chem., 14, 41 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (3R,4S)-4-(methylamino)-1-phenylpent-1-en-3-ol | - |
Aspergillus niger |  |
| (3R,4S)-4-(methylamino)-1-phenylpent-1-en-3-ol | - |
Candida albicans | |
| (3R,4S)-4-(methylamino)-1-phenylpent-1-en-3-ol | - |
Escherichia coli | |
| (3R,4S)-4-(methylamino)-1-phenylpent-1-en-3-ol | - |
Proteus mirabilis | |
| (3R,4S)-4-(methylamino)-1-phenylpent-1-en-3-ol | - |
Pseudomonas aeruginosa | |
| (3R,4S)-4-(methylamino)-1-phenylpent-1-en-3-ol | - |
Staphylococcus aureus | |
| (4S)-2-methyl-2-phenylpentane-1,4-diol | - |
Aspergillus niger | |
| (4S)-2-methyl-2-phenylpentane-1,4-diol | - |
Candida albicans | |
| (4S)-2-methyl-2-phenylpentane-1,4-diol | - |
Escherichia coli | |
| (4S)-2-methyl-2-phenylpentane-1,4-diol | - |
Proteus mirabilis | |
| (4S)-2-methyl-2-phenylpentane-1,4-diol | - |
Pseudomonas aeruginosa | |
| (4S)-2-methyl-2-phenylpentane-1,4-diol | - |
Staphylococcus aureus | |
| 2-(4-hydroxyphenyl)-4-(4-nitrophenylimino)chroman-5,7-diol | - |
Aspergillus niger | |
| 2-(4-hydroxyphenyl)-4-(4-nitrophenylimino)chroman-5,7-diol | - |
Candida albicans | |
| 2-(4-hydroxyphenyl)-4-(4-nitrophenylimino)chroman-5,7-diol | - |
Escherichia coli | |
| 2-(4-hydroxyphenyl)-4-(4-nitrophenylimino)chroman-5,7-diol | - |
Proteus mirabilis | |
| 2-(4-hydroxyphenyl)-4-(4-nitrophenylimino)chroman-5,7-diol | - |
Pseudomonas aeruginosa | |
| 2-(4-hydroxyphenyl)-4-(4-nitrophenylimino)chroman-5,7-diol | - |
Staphylococcus aureus | |
| 3-(tert-butoxycarbonyl)-6-(3-benzoylprop-2-yl)phenol | - |
Aspergillus niger | |
| 3-(tert-butoxycarbonyl)-6-(3-benzoylprop-2-yl)phenol | - |
Candida albicans | |
| 3-(tert-butoxycarbonyl)-6-(3-benzoylprop-2-yl)phenol | - |
Escherichia coli | |
| 3-(tert-butoxycarbonyl)-6-(3-benzoylprop-2-yl)phenol | - |
Proteus mirabilis | |
| 3-(tert-butoxycarbonyl)-6-(3-benzoylprop-2-yl)phenol | - |
Pseudomonas aeruginosa | |
| 3-(tert-butoxycarbonyl)-6-(3-benzoylprop-2-yl)phenol | - |
Staphylococcus aureus | |
| 4-(1,3-dihydroxypropan-2-ylimino)-2-(4-hydroxyphenyl)chroman-5,7-diol | - |
Aspergillus niger | |
| 4-(1,3-dihydroxypropan-2-ylimino)-2-(4-hydroxyphenyl)chroman-5,7-diol | - |
Candida albicans | |
| 4-(1,3-dihydroxypropan-2-ylimino)-2-(4-hydroxyphenyl)chroman-5,7-diol | - |
Escherichia coli | |
| 4-(1,3-dihydroxypropan-2-ylimino)-2-(4-hydroxyphenyl)chroman-5,7-diol | - |
Proteus mirabilis | |
| 4-(1,3-dihydroxypropan-2-ylimino)-2-(4-hydroxyphenyl)chroman-5,7-diol | - |
Pseudomonas aeruginosa | |
| 4-(1,3-dihydroxypropan-2-ylimino)-2-(4-hydroxyphenyl)chroman-5,7-diol | - |
Staphylococcus aureus | |
| 4-(2-chlorophenylimino)-2-(4-hydroxyphenyl)chroman-5,7-diol | - |
Aspergillus niger | |
| 4-(2-chlorophenylimino)-2-(4-hydroxyphenyl)chroman-5,7-diol | - |
Candida albicans | |
| 4-(2-chlorophenylimino)-2-(4-hydroxyphenyl)chroman-5,7-diol | - |
Escherichia coli | |
| 4-(2-chlorophenylimino)-2-(4-hydroxyphenyl)chroman-5,7-diol | - |
Proteus mirabilis | |
| 4-(2-chlorophenylimino)-2-(4-hydroxyphenyl)chroman-5,7-diol | - |
Pseudomonas aeruginosa | |
| 4-(2-chlorophenylimino)-2-(4-hydroxyphenyl)chroman-5,7-diol | - |
Staphylococcus aureus | |
| 4-(2-fluorophenylimino)-2-(4-hydroxyphenyl)chroman-5,7-diol | - |
Aspergillus niger | |
| 4-(2-fluorophenylimino)-2-(4-hydroxyphenyl)chroman-5,7-diol | - |
Candida albicans | |
| 4-(2-fluorophenylimino)-2-(4-hydroxyphenyl)chroman-5,7-diol | - |
Escherichia coli | |
| 4-(2-fluorophenylimino)-2-(4-hydroxyphenyl)chroman-5,7-diol | - |
Proteus mirabilis | |
| 4-(2-fluorophenylimino)-2-(4-hydroxyphenyl)chroman-5,7-diol | - |
Pseudomonas aeruginosa | |
| 4-(2-fluorophenylimino)-2-(4-hydroxyphenyl)chroman-5,7-diol | - |
Staphylococcus aureus | |
| 7-methoxy-2,3-dihydro-2-phenyl-4 quinolone | - |
Aspergillus niger | |
| 7-methoxy-2,3-dihydro-2-phenyl-4 quinolone | - |
Candida albicans | |
| 7-methoxy-2,3-dihydro-2-phenyl-4 quinolone | - |
Escherichia coli | |
| 7-methoxy-2,3-dihydro-2-phenyl-4 quinolone | - |
Proteus mirabilis | |
| 7-methoxy-2,3-dihydro-2-phenyl-4 quinolone | - |
Pseudomonas aeruginosa | |
| 7-methoxy-2,3-dihydro-2-phenyl-4 quinolone | - |
Staphylococcus aureus | |
| catechin | - |
Aspergillus niger | |
| catechin | - |
Candida albicans | |
| catechin | - |
Escherichia coli | |
| catechin | - |
Proteus mirabilis | |
| catechin | - |
Pseudomonas aeruginosa | |
| catechin | - |
Staphylococcus aureus | |
| L-ascorbic acid | - |
Aspergillus niger | |
| L-ascorbic acid | - |
Candida albicans | |
| L-ascorbic acid | - |
Escherichia coli | |
| L-ascorbic acid | - |
Proteus mirabilis | |
| L-ascorbic acid | - |
Pseudomonas aeruginosa | |
| L-ascorbic acid | - |
Staphylococcus aureus | |
| luteolin | - |
Aspergillus niger | |
| luteolin | - |
Candida albicans | |
| luteolin | - |
Escherichia coli | |
| luteolin | - |
Proteus mirabilis | |
| luteolin | - |
Pseudomonas aeruginosa | |
| luteolin | - |
Staphylococcus aureus | |
| additional information | synthesis of naringenin derivatives with potent glucosamine-6-phosphate synthase inhibitory capacities and antioxidant, antimicrobial, and preservative efficacy. Molecular docking and in silico ADMET analysis, structure-activity relationship studies, overview. MIC values for growth inhibition of the cells | Aspergillus niger | |
| additional information | synthesis of naringenin derivatives with potent glucosamine-6-phosphate synthase inhibitory capacities and antioxidant, antimicrobial, and preservative efficacy. Molecular docking and in silico ADMET analysis, structure-activity relationship studies, overview. MIC values for growth inhibition of the cells | Candida albicans | |
| additional information | synthesis of naringenin derivatives with potent glucosamine-6-phosphate synthase inhibitory capacities and antioxidant, antimicrobial, and preservative efficacy. Molecular docking and in silico ADMET analysis, structure-activity relationship studies, overview. MIC values for growth inhibition of the cells | Escherichia coli | |
| additional information | synthesis of naringenin derivatives with potent glucosamine-6-phosphate synthase inhibitory capacities and antioxidant, antimicrobial, and preservative efficacy. Molecular docking and in silico ADMET analysis, structure-activity relationship studies, overview. MIC values for growth inhibition of the cells | Proteus mirabilis | |
| additional information | synthesis of naringenin derivatives with potent glucosamine-6-phosphate synthase inhibitory capacities and antioxidant, antimicrobial, and preservative efficacy. Molecular docking and in silico ADMET analysis, structure-activity relationship studies, overview. MIC values for growth inhibition of the cells | Pseudomonas aeruginosa | |
| additional information | synthesis of naringenin derivatives with potent glucosamine-6-phosphate synthase inhibitory capacities and antioxidant, antimicrobial, and preservative efficacy. Molecular docking and in silico ADMET analysis, structure-activity relationship studies, overview. MIC values for growth inhibition of the cells | Staphylococcus aureus | |
| naringenin | - |
Aspergillus niger | |
| naringenin | - |
Candida albicans | |
| naringenin | - |
Escherichia coli | |
| naringenin | - |
Proteus mirabilis | |
| naringenin | - |
Pseudomonas aeruginosa | |
| naringenin | - |
Staphylococcus aureus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamine + D-fructose 6-phosphate | Escherichia coli | - |
L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | Candida albicans | - |
L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | Proteus mirabilis | - |
L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | Pseudomonas aeruginosa | - |
L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | Staphylococcus aureus | - |
L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | Aspergillus niger | - |
L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | Pseudomonas aeruginosa ATCC 15692 | - |
L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | Staphylococcus aureus MRSA252 | - |
L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | Proteus mirabilis HI4320 | - |
L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | Pseudomonas aeruginosa 1C | - |
L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | Candida albicans ATCC MYA-2876 | - |
L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | Pseudomonas aeruginosa PRS 101 | - |
L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | Aspergillus niger FGSC A1513 | - |
L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | Pseudomonas aeruginosa DSM 22644 | - |
L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | Pseudomonas aeruginosa CIP 104116 | - |
L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | Pseudomonas aeruginosa LMG 12228 | - |
L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | Aspergillus niger CBS 513.88 | - |
L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | Pseudomonas aeruginosa JCM 14847 | - |
L-glutamate + D-glucosamine 6-phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus niger | A2QH83 | - |
- |
| Aspergillus niger CBS 513.88 | A2QH83 | - |
- |
| Aspergillus niger FGSC A1513 | A2QH83 | - |
- |
| Candida albicans | P53704 | - |
- |
| Candida albicans ATCC MYA-2876 | P53704 | - |
- |
| Escherichia coli | P17169 | - |
- |
| Proteus mirabilis | B4F0F0 | - |
- |
| Proteus mirabilis HI4320 | B4F0F0 | - |
- |
| Pseudomonas aeruginosa | Q9HT25 | - |
- |
| Pseudomonas aeruginosa 1C | Q9HT25 | - |
- |
| Pseudomonas aeruginosa ATCC 15692 | Q9HT25 | - |
- |
| Pseudomonas aeruginosa CIP 104116 | Q9HT25 | - |
- |
| Pseudomonas aeruginosa DSM 22644 | Q9HT25 | - |
- |
| Pseudomonas aeruginosa JCM 14847 | Q9HT25 | - |
- |
| Pseudomonas aeruginosa LMG 12228 | Q9HT25 | - |
- |
| Pseudomonas aeruginosa PRS 101 | Q9HT25 | - |
- |
| Staphylococcus aureus | Q6GES3 | - |
- |
| Staphylococcus aureus MRSA252 | Q6GES3 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamine + D-fructose 6-phosphate | - |
Escherichia coli | L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | - |
Candida albicans | L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | - |
Proteus mirabilis | L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | - |
Pseudomonas aeruginosa | L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | - |
Staphylococcus aureus | L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | - |
Aspergillus niger | L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | - |
Pseudomonas aeruginosa ATCC 15692 | L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | - |
Staphylococcus aureus MRSA252 | L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | - |
Proteus mirabilis HI4320 | L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | - |
Pseudomonas aeruginosa 1C | L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | - |
Candida albicans ATCC MYA-2876 | L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | - |
Pseudomonas aeruginosa PRS 101 | L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | - |
Aspergillus niger FGSC A1513 | L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | - |
Pseudomonas aeruginosa DSM 22644 | L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | - |
Pseudomonas aeruginosa CIP 104116 | L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | - |
Pseudomonas aeruginosa LMG 12228 | L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | - |
Aspergillus niger CBS 513.88 | L-glutamate + D-glucosamine 6-phosphate | - |
? | |
| L-glutamine + D-fructose 6-phosphate | - |
Pseudomonas aeruginosa JCM 14847 | L-glutamate + D-glucosamine 6-phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| G-6-P synthase | - |
Escherichia coli |
| G-6-P synthase | - |
Candida albicans |
| G-6-P synthase | - |
Proteus mirabilis |
| G-6-P synthase | - |
Pseudomonas aeruginosa |
| G-6-P synthase | - |
Staphylococcus aureus |
| G-6-P synthase | - |
Aspergillus niger |
| glucosamine-6-phosphate synthase | - |
Escherichia coli |
| glucosamine-6-phosphate synthase | - |
Candida albicans |
| glucosamine-6-phosphate synthase | - |
Proteus mirabilis |
| glucosamine-6-phosphate synthase | - |
Pseudomonas aeruginosa |
| glucosamine-6-phosphate synthase | - |
Staphylococcus aureus |
| glucosamine-6-phosphate synthase | - |
Aspergillus niger |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
in vivo assay at | Escherichia coli |
| 37 | - |
in vivo assay at | Candida albicans |
| 37 | - |
in vivo assay at | Proteus mirabilis |
| 37 | - |
in vivo assay at | Pseudomonas aeruginosa |
| 37 | - |
in vivo assay at | Staphylococcus aureus |
| 37 | - |
in vivo assay at | Aspergillus niger |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | glucosamine-6-phosphate synthase is an important enzyme for bacterial and fungal cell wall synthesis | Escherichia coli |
| physiological function | glucosamine-6-phosphate synthase is an important enzyme for bacterial and fungal cell wall synthesis | Candida albicans |
| physiological function | glucosamine-6-phosphate synthase is an important enzyme for bacterial and fungal cell wall synthesis | Proteus mirabilis |
| physiological function | glucosamine-6-phosphate synthase is an important enzyme for bacterial and fungal cell wall synthesis | Pseudomonas aeruginosa |
| physiological function | glucosamine-6-phosphate synthase is an important enzyme for bacterial and fungal cell wall synthesis | Staphylococcus aureus |
| physiological function | glucosamine-6-phosphate synthase is an important enzyme for bacterial and fungal cell wall synthesis | Aspergillus niger |
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