Literature summary for 2.6.1.16 extracted from

Ellis, D.B.; Sommar, K.M.
Biosynthesis of respiratory tract musins. II. Control of hexosamine metabolism by L-glutamine D-fructose 6-phosphate aminotransferase (1972), Biochim. Biophys. Acta, 267, 105-112.

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General Stability

General Stability	Organism
glucose 6-phosphate, 12 mM, required as protective agent during purification	Bos taurus

Inhibitors

Inhibitors	Comment	Organism	Structure
6-diazo-5-oxo-L-norleucine	-	Bos taurus
UDP-N-acetylglucosamine	partial	Bos taurus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.2	-	L-glutamine	pH 7.4, 37°C	Bos taurus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
350000	-	-	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
trachea	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-glutamine + D-fructose 6-phosphate	-	Bos taurus	L-glutamate + D-glucosamine 6-phosphate	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Bos taurus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.5	7.5	-	Bos taurus

pH Range

pH Minimum	pH Maximum	Comment	Organism
6	8.5	-	Bos taurus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.001	-	6-diazo-5-oxo-L-norleucine	pH 7.4, 37°C	Bos taurus
0.04	-	UDP-N-acetylglucosamine	pH 7.4, 37°C	Bos taurus

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Release 2023.1 (January 2023)