BRENDA - Enzyme Database show
show all sequences of 2.6.1.13

Molecular and functional analyses support a role of Ornithine-delta-aminotransferase in the provision of glutamate for glutamine biosynthesis during pine germination

Canas, R.A.; Villalobos, D.P.; Diaz-Moreno, S.M.; Canovas, F.M.; Canton, F.R.; Plant Physiol. 148, 77-88 (2008)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression in Escherichia coli
Pinus sylvestris
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
no Michaelis-Menten kinetics are obtained, possibly a positive cooperative behavior with kinetic values S0.5 of 0.8mM for 2-oxoglutarate and S0.5 of 6.3 mM for ornithine
Pinus sylvestris
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
49000
-
x * 51200, calculated, x * 49000, SDS-PAGE
Pinus sylvestris
51200
-
x * 51200, calculated, x * 49000, SDS-PAGE
Pinus sylvestris
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Pinus sylvestris
Q1RPP3
-
-
Posttranslational Modification
Posttranslational Modification
Commentary
Organism
additional information
sequence contains a putative N-terminal signal peptide for mitochondrial targeting
Pinus sylvestris
Source Tissue
Source Tissue
Commentary
Organism
Textmining
embryo
expression is undetectable in the embryo, but increase of activity is observed in germinating embryos and seedlings
Pinus sylvestris
-
seedling
expression is highly induced at early stages of germination and seedling development in all different organs. An increase of activity is observed in germinating embryos and seedlings
Pinus sylvestris
-
stem
increase in transcript level in lignified stems of 90-d-old plants
Pinus sylvestris
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-ornithine + 2-oxoglutarate
-
689633
Pinus sylvestris
L-glutamate + DELTA1-pyrroline-5-carboxylate
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 51200, calculated, x * 49000, SDS-PAGE
Pinus sylvestris
pI Value
Organism
Commentary
pI Value Maximum
pI Value
Pinus sylvestris
calculated
-
7.5
Cloned(Commentary) (protein specific)
Commentary
Organism
expression in Escherichia coli
Pinus sylvestris
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
additional information
-
additional information
no Michaelis-Menten kinetics are obtained, possibly a positive cooperative behavior with kinetic values S0.5 of 0.8mM for 2-oxoglutarate and S0.5 of 6.3 mM for ornithine
Pinus sylvestris
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
49000
-
x * 51200, calculated, x * 49000, SDS-PAGE
Pinus sylvestris
51200
-
x * 51200, calculated, x * 49000, SDS-PAGE
Pinus sylvestris
Posttranslational Modification (protein specific)
Posttranslational Modification
Commentary
Organism
additional information
sequence contains a putative N-terminal signal peptide for mitochondrial targeting
Pinus sylvestris
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
embryo
expression is undetectable in the embryo, but increase of activity is observed in germinating embryos and seedlings
Pinus sylvestris
-
seedling
expression is highly induced at early stages of germination and seedling development in all different organs. An increase of activity is observed in germinating embryos and seedlings
Pinus sylvestris
-
stem
increase in transcript level in lignified stems of 90-d-old plants
Pinus sylvestris
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
L-ornithine + 2-oxoglutarate
-
689633
Pinus sylvestris
L-glutamate + DELTA1-pyrroline-5-carboxylate
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 51200, calculated, x * 49000, SDS-PAGE
Pinus sylvestris
pI Value (protein specific)
Organism
Commentary
pI Value Maximum
pI Value
Pinus sylvestris
calculated
-
7.5
Other publictions for EC 2.6.1.13
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
738432
Peng
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Xenopus laevis
Invest. Ophthalmol. Vis. Sci.
56
2486-2497
2015
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1
1
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-
739425
Hampel
Mycobacterium tuberculosis is ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
PLoS ONE
10
e0136914
2015
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155
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1
1
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737430
Juncosa
Two continuous coupled assays ...
Homo sapiens
Anal. Biochem.
440
145-149
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1
2
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1
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737967
da Silva
The effect of portacaval anast ...
Rattus norvegicus
Can. J. Physiol. Pharmacol.
91
362-368
2013
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1
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723051
da Rocha
Exogenous ornithine is an effe ...
Anacardium occidentale
J. Plant Physiol.
169
41-49
2012
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1
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1
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1
1
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-
-
723382
Senthil-Kumar
Ornithine-delta-aminotransfera ...
Arabidopsis thaliana, Nicotiana benthamiana
Plant Cell Environ.
35
1329-1343
2012
-
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6
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2
4
4
2
-
-
721263
Ventura
Adaptative response of nitroge ...
Homo sapiens
Amino Acids
39
1417-1426
2010
-
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4
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1
1
-
-
-
721755
Stranska
Biochemical characterization o ...
Pisum sativum
Biochimie
92
940-948
2010
-
-
1
-
-
-
8
1
-
-
1
-
-
5
-
-
1
-
-
-
-
-
1
-
1
-
1
1
1
-
-
1
8
-
-
-
-
1
1
-
-
-
-
8
8
1
-
-
1
-
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1
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-
1
-
1
-
1
1
1
-
-
-
-
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-
-
1
1
722970
Jortzik
Redox regulation of Plasmodium ...
Plasmodium falciparum
J. Mol. Biol.
402
445-459
2010
-
-
-
1
6
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-
8
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1
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4
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1
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1
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1
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1
6
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8
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4
-
1
-
1
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-
1
-
-
-
-
-
-
-
3
3
685859
Ventura
Overexpression of ornithine am ...
Homo sapiens, Mus musculus
Br. J. Nutr.
101
843-851
2009
-
2
-
-
2
-
-
4
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7
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2
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2
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4
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2
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-
703993
Ravi Kumar
A sensitive assay for ornithin ...
Rattus norvegicus
Indian J. Clin. Biochem.
24
275-279
2009
-
1
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-
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2
2
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1
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3
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9
9
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1
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1
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1
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1
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1
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1
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2
2
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1
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9
9
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1
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1
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1
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1
1
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704292
Fonknechten
A conserved gene cluster rules ...
Acetoanaerobium sticklandii
J. Bacteriol.
191
3162-3167
2009
-
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1
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1
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1
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1
1
-
-
-
685833
Funck
Ornithine-delta-aminotransfera ...
Arabidopsis thaliana
BMC Plant Biol.
8
40
2008
-
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1
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1
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1
-
3
-
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1
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1
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688566
Dekaney
Regulation of ornithine aminot ...
Homo sapiens
J. Nutr. Biochem.
19
674-681
2008
1
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2
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1
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-
689633
Canas
Molecular and functional analy ...
Pinus sylvestris
Plant Physiol.
148
77-88
2008
-
-
1
-
-
-
-
1
-
-
2
-
-
5
-
1
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-
3
-
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1
1
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1
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1
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1
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3
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1
1
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1
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703992
Ravikumar
Effect of pH on spectral chara ...
Homo sapiens
Indian J. Clin. Biochem.
23
117-122
2008
-
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2
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2
3
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1
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2
3
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1
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1
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706356
Stranska
Ornithine delta-aminotransfera ...
Arabidopsis thaliana, Cucurbita pepo, Homo sapiens, Nicotiana plumbaginifolia, Oryza sativa, Pisum sativum, Vigna aconitifolia
Plant Signal. Behav.
3
929-935
2008
2
7
4
1
1
-
8
4
7
-
1
7
-
13
-
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1
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7
2
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2
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7
-
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2
7
4
7
1
1
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8
-
4
7
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1
7
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1
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7
2
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2
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5
5
-
-
-
671263
Levillain
Sex-differential expression of ...
Mus musculus
Am. J. Physiol. Renal Physiol.
292
F1016-F1027
2007
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1
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1
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1
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1
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4
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4
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676887
Wang
Diazonamide toxins reveal an u ...
Homo sapiens, Xenopus sp.
Proc. Natl. Acad. Sci. USA
104
2068-2073
2007
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2
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4
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2
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5
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2
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-
688463
Sekhar
Biochemical characterization, ...
Vigna aconitifolia
J. Mol. Graph. Model.
26
709-719
2007
1
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1
1
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4
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6
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1
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1
1
1
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1
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1
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1
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4
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2
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1
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1
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1
1
1
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1
-
-
-
-
-
-
-
-
-
689114
Wagemaker
The role of ornithine aminotra ...
Agaricus bisporus
Mycol. Res.
111
909-918
2007
-
-
-
-
1
-
-
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-
-
1
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4
-
1
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1
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1
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1
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1
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-
661604
Levillain
Testosterone down-regulates or ...
Mus musculus
Endocrinology
146
950-959
2005
-
1
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4
-
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1
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663174
Wu
Over-expression of the bacteri ...
Arabidopsis thaliana
Plant Sci.
168
297-302
2005
-
1
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Ohkubo
Vitamin B6-responsive ornithin ...
Homo sapiens
Tohoku J. Exp. Med.
205
335-342
2005
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674489
Markova
Determinants of substrate spec ...
Homo sapiens
J. Biol. Chem.
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660684
Levillain
Ornithine metabolism in male a ...
Rattus norvegicus
Am. J. Physiol. Renal. Physiol.
286
F727-738
2004
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637134
Roosens
Overexpression of ornithine-de ...
Arabidopsis thaliana
Mol. Breed.
9
73-80
2002
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1
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637127
Dekaney
Ornithine aminotransferase mes ...
Sus scrofa
Pediatr. Res.
50
104-109
2001
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637128
Gafan
Characterization of the ornith ...
Plasmodium falciparum
Mol. Biochem. Parasitol.
118
1-10
2001
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1
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637131
Levillain
Ornithine metabolism along the ...
Mus musculus
Pflugers Arch.
440
761-769
2000
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637133
Madan
-
Properties of partially purifi ...
Brassica juncea
Acta Physiol. Plant.
22
444-450
2000
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637136
Roschinger
Characteristics of L-ornithine ...
Homo sapiens, Rattus norvegicus
Clin. Chim. Acta
296
91-100
2000
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5
4
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637137
Seiler
Ornithine aminotransferase, a ...
Homo sapiens, Rattus norvegicus
Curr. Drug Targets
1
119-153
2000
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1
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7
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3
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2
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637140
Storici
Crystal structure of human orn ...
Homo sapiens
J. Mol. Biol.
285
297-309
1999
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637141
Yang
-
Importance of ornithine-delta- ...
Oryza sativa
Plant Growth Regul.
27
189-192
1999
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2
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637129
Heinanen
Gyrate atrophy of the choroid ...
Homo sapiens
Pediatr. Res.
44
381-385
1998
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2
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637132
Lim
A variant of ornithine aminotr ...
Mus musculus
Exp. Mol. Med.
30
131-135
1998
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2
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1
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637135
Roosens
Isolation of the ornithine-d-a ...
Arabidopsis thaliana
Plant Physiol.
117
263-271
1998
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637139
Shen
Crystal structure of human rec ...
Homo sapiens
J. Mol. Biol.
277
81-102
1998
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1
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637138
Shah
Human ornithine aminotransfera ...
Homo sapiens
Structure
5
1067-1075
1997
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1
1
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637130
Jhee
Thermostable ornithine aminotr ...
Bacillus sp. (in: Bacteria), Bacillus sp. (in: Bacteria) YM-2
J. Biochem.
118
101-108
1995
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2
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5
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1
1
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1
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10
1
1
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1
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1
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2
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2
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1
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1
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10
1
1
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637113
Hervieu
-
Inhibition of plant ornithine ...
Raphanus sativus
Phytochemistry
34
1231-1234
1993
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2
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1
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2
1
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1
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2
1
-
1
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-
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637100
Kanda
-
Purification and properties of ...
Brevibacillus brevis
Enzymes Depend. Pyridoxal Phosphate Other Carbonyl Compd. Cofactors, Proc. Int. Symp. Vitamin B6 Carbonyl Catal. , Meeting Date 1990 (Fukui, T. , ed. ), Pergamon, Oxford
8
241-243
1991
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1
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1
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1
1
-
-
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637120
Rosenthal
Interaction of L-canaline with ...
Manduca sexta
J. Biol. Chem.
265
868-873
1990
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1
2
2
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2
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2
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1
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1
1
2
1
1
1
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2
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1
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1
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1
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2
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2
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2
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1
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1
1
2
1
1
1
-
-
2
-
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-
-
-
-
-
-
-
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637101
Sharma
-
Ornithine aminotransferase of ...
Ancylostoma ceylanicum, Nippostrongylus brasiliensis
Indian J. Parasitol.
12
237-242
1988
-
-
-
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2
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2
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2
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2
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2
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2
-
-
-
-
-
2
-
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637114
Daune
5-Fluoromethylornithine, an ir ...
Mus musculus, Rattus norvegicus
Biochem. J.
253
481-488
1988
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2
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4
1
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2
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1
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2
1
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1
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4
1
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2
-
-
-
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-
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637124
Burcham
Comparison of rat and mouse or ...
Mus musculus, Rattus norvegicus
Arch. Biochem. Biophys.
262
501-507
1988
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1
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4
2
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5
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2
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2
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2
2
2
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2
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1
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4
2
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2
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2
-
2
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2
2
2
-
-
-
2
-
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637116
Marcovic-Housley
Quaternary structure of ornith ...
Rattus norvegicus
Eur. J. Biochem.
162
345-350
1987
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1
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2
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2
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1
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2
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1
1
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1
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2
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1
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2
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1
1
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-
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-
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-
-
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637102
Park
-
Characterization of bovine liv ...
Bos taurus
Han'guk Saenghwa Hak Hoe Chi
18
351-360
1985
-
-
-
-
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-
1
2
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2
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1
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1
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-
1
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1
1
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1
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-
1
1
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1
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1
1
2
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2
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1
-
1
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-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
637103
Kim
-
Studies on the ornithine amino ...
Gallus gallus
Han'guk Saenghwa Hak Hoe Chi
18
109-115
1985
-
-
-
-
-
-
2
2
-
-
2
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1
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1
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3
1
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1
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2
-
2
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2
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1
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-
3
1
-
-
-
-
1
-
-
-
-
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-
-
-
-
637126
Cooper
Glutamate-ornithine transamina ...
Neurospora crassa, Rattus norvegicus
Methods Enzymol.
113
76-79
1985
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-
-
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1
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2
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6
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4
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1
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6
-
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4
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
637118
Matsuzawa
Ornithine oxoacid aminotransfe ...
Homo sapiens, Rattus norvegicus, Rattus norvegicus Wistar
Biochim. Biophys. Acta
714
356-360
1982
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15
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167
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6
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3
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15
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6
-
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3
-
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-
-
-
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-
-
-
-
-
-
-
-
637119
Williams
The reaction of ornithine amin ...
Rattus norvegicus
Biochem. J.
201
221-225
1982
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637122
Ohura
Crystallization and properties ...
Homo sapiens, Rattus norvegicus
J. Biochem.
92
1785-1792
1982
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1
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2
1
2
2
2
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2
1
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637104
Shiono
Partial purification and certa ...
Bos taurus
Exp. Eye Res.
32
475-490
1981
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1
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637117
Boernke
Effects of self-association of ...
Rattus norvegicus
Biochemistry
20
115-121
1981
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1
1
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637121
Yasuda
Properties of crystalline L-or ...
Erwinia aroidea, Lysinibacillus sphaericus, Lysinibacillus sphaericus IFO3525, Staphylococcus aureus
J. Bacteriol.
148
43-50
1981
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1
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12
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2
2
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5
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13
1
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1
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12
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13
1
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637105
Yasuda
-
Purification and crystallizati ...
Clavibacter michiganensis subsp. sepedonicus
Bull. Inst. Chem. Res.
58
366-370
1980
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637106
Goldberg
-
Ornithine-DELTA-transaminase f ...
Fasciola hepatica, Schistosoma mansoni
Comp. Biochem. Physiol. B
65
605-613
1980
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2
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2
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2
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637112
Yasuda
-
Irreversible inactivation of L ...
Lysinibacillus sphaericus
Agric. Biol. Chem.
44
3005-3006
1980
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637107
Goldberg
Schistosoma mansoni: partial p ...
Schistosoma mansoni
Exp. Parasitol.
47
333-341
1979
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1
7
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7
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1
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637111
Yasuda
Purification and crystallizati ...
Lysinibacillus sphaericus
FEBS Lett.
105
209-212
1979
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27
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27
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637125
Kito
Mode of inhibition of ornithin ...
Rattus norvegicus
J. Biochem.
83
201-206
1978
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4
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3
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637123
Kalita
Preparation and properties of ...
Rattus norvegicus
Biochim. Biophys. Acta
429
780-797
1976
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1
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19
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637108
Lu
L-ornithine 2-oxoacid aminotra ...
Cucurbita pepo
Plant Physiol.
55
502-506
1975
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3
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637115
Matsuzawa
Characteristics of the inhibit ...
Rattus norvegicus
J. Biochem.
75
601-609
1974
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4
3
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2
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637110
Stevens
-
Induction, partial purificatio ...
Aspergillus nidulans
Biochem. Soc. Trans.
1
749-751
1973
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2
2
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8
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8
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637109
Peraino
Functional properties of ornit ...
Rattus norvegicus
Biochim. Biophys. Acta
289
117-127
1972
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637099
Peraino
Chemical, physical, and morpho ...
Rattus norvegicus
J. Biol. Chem.
244
2241-2249
1969
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1
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1
1
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637098
Strecker
Purification and properties of ...
Rattus norvegicus
J. Biol. Chem.
240
1225-1230
1965
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2
15
6
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1
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1
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2
1
1
11
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1
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2
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15
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6
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1
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1
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2
1
1
11
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1
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