Application | Comment | Organism |
---|---|---|
medicine | transgenic mice that specifically overexpress human ornithine aminotransferase in the liver, kidneys and intestine exhibit higher enzyme activity in the liver than wild-type, but there are no differences in kinetic parameters between wild-type and transgenic animal. Ornithine aminotransferase overexpression decreases plasma and liver ornithine concentrations but does not affect glutamine or arginine homeostasis. There is an inverse relationship between ornithine levels and enzyme activity | Mus musculus |
medicine | transgenic mice that specifically overexpress human ornithine aminotransferase in the liver, kidneys and intestine exhibit higher enzyme activity in the liver than wild-type, but there are no differences in kinetic parameters between wild-type and transgenic animal. Ornithine aminotransferase overexpression decreases plasma and liver ornithine concentrations but does not affect glutamine or arginine homeostasis. There is an inverse relationship between ornithine levels and enzyme activity | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | transgenic mice that specifically overexpress human ornithine aminotransferase in the liver, kidneys and intestine exhibit higher enzyme activity in the liver than wild-type, but there are no differences in kinetic parameters between wild-type and transgenic animal. Ornithine aminotransferase overexpression decreases plasma and liver ornithine concentrations but does not affect glutamine or arginine homeostasis. There is an inverse relationship between ornithine levels and enzyme activity | Mus musculus |
additional information | transgenic mice that specifically overexpress human ornithine aminotransferase in the liver, kidneys and intestine exhibit higher enzyme activity in the liver than wild-type, but there are no differences in kinetic parameters between wild-type and transgenic animal. Ornithine aminotransferase overexpression decreases plasma and liver ornithine concentrations but does not affect glutamine or arginine homeostasis. There is an inverse relationship between ornithine levels and enzyme activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
2.17 | - |
2-oxoglutarate | wild-type, pH 7.5, 37°C | Mus musculus | |
2.69 | - |
2-oxoglutarate | transgenic mouse, pH 7.5, 37°C | Homo sapiens | |
13.94 | - |
L-ornithine | wild-type, pH 7.5, 37°C | Mus musculus | |
15.32 | - |
L-ornithine | transgenic mouse, pH 7.5, 37°C | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-ornithine + 2-oxoglutarate | - |
Mus musculus | glutamate + DELTA1-pyrroline-5-carboxylate | - |
? | |
L-ornithine + 2-oxoglutarate | - |
Homo sapiens | glutamate + DELTA1-pyrroline-5-carboxylate | - |
? |