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Literature summary for 2.6.1.116 extracted from

  • akehara, I.; Fujii, T.; Tanimoto, Y.; Kato, D.I.; Takeo, M.; Negoro, S.
    Metabolic pathway of 6-aminohexanoate in the nylon oligomer-degrading bacterium Arthrobacter sp. KI72 identification of the enzymes responsible for the conversion of 6-aminohexanoate to adipate (2018), Appl. Microbiol. Biotechnol., 102, 801-814 .
    View publication on PubMed
Search for more literature for 2.6.1.116

Application

Application Comment Organism
degradation strain KI72 grows on a 6-aminohexanoate oligomer, a by-product of nylon-6 manufacturing, as a sole source of carbon and nitrogen Paenarthrobacter ureafaciens
synthesis a coupled system of NylD1 and adipate semialdehyde dehydrogenase NylE1 allows to quantify the aminotransferase activity and enables the conversion of 6-aminohexaoate to adipate via adipate semialdehyde with a yield of >90% Paenarthrobacter ureafaciens

Cloned(Commentary)

Cloned (Comment) Organism
expresssion in Escherichia coli Paenarthrobacter ureafaciens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
6-aminohexanoate + 2-oxoglutarate Paenarthrobacter ureafaciens
-
 6-oxohexanoate + L-glutamate
-
 ?
6-aminohexanoate + 2-oxoglutarate Paenarthrobacter ureafaciens NBRC 14590
-
 6-oxohexanoate + L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Paenarthrobacter ureafaciens
-
-
-
Paenarthrobacter ureafaciens NBRC 14590
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6-aminohexanoate + 2-oxoglutarate
-
 Paenarthrobacter ureafaciens 6-oxohexanoate + L-glutamate
-
 ?
6-aminohexanoate + 2-oxoglutarate
-
 Paenarthrobacter ureafaciens NBRC 14590 6-oxohexanoate + L-glutamate
-
 ?
6-aminohexanoate + glyoxylate
-
 Paenarthrobacter ureafaciens 6-oxohexanoate + glycine
-
 ?
6-aminohexanoate + glyoxylate
-
 Paenarthrobacter ureafaciens NBRC 14590 6-oxohexanoate + glycine
-
 ?
6-aminohexanoate + pyruvate
-
 Paenarthrobacter ureafaciens 6-oxohexanoate + L-alanine
-
 ?
6-aminohexanoate + pyruvate
-
 Paenarthrobacter ureafaciens NBRC 14590 6-oxohexanoate + L-alanine
-
 ?

Synonyms

Synonyms Comment Organism
NylD1
-
 Paenarthrobacter ureafaciens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Paenarthrobacter ureafaciens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
 assay at Paenarthrobacter ureafaciens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Paenarthrobacter ureafaciens

General Information

General Information Comment Organism
physiological function enzyme is a member of the PLP-dependent aminotransferase subgroup III Paenarthrobacter ureafaciens