Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | cytosolic Hsp70, from bovine brain, protein exclusively binds to the mitochondrial isozyme, regulatory function | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | mature isozyme mAAT | Rattus norvegicus | 5739 | - |
mitochondrion | mitochondrial isoenzyme | Rattus norvegicus | 5739 | - |
additional information | cytosolic and mitochondrial isozymes bind differently to the 70 kDa heat shock protein Hsp70, which regulates the folding and aggregation process of polypeptides, sequence and distribution of Hsp70-binding regions allow the classification of isozymes into a phylogenetic tree, overview | Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate + 2-oxoglutarate | Rattus norvegicus | - |
oxaloacetate + L-glutamate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
purified premature mitochondrial isozyme pmAAT | - |
Rattus norvegicus | P00507 | mature mitochondrial isozyme mAAT | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | premature and mature mitochondrial isozyme | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-aspartate + 2-oxoglutarate | - |
Rattus norvegicus | oxaloacetate + L-glutamate | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | a pyridoxal 5'-phosphate protein | Rattus norvegicus |