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Literature summary for 2.5.1.93 extracted from
- Geranyl diphosphate:4-hydroxybenzoate geranyltransferase from Lithospermum erythrorhizon. Cloning and characterization of a ket enzyme in shikonin biosynthesis (2001), J. Biol. Chem., 277, 6240-6246.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| functional expression of LePGTs in a yeast COQ2 disruptant | Lithospermum erythrorhizon |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0051 | - |
geranyl diphosphate | - |
Lithospermum erythrorhizon |  |
| 0.0103 | - |
4-hydroxybenzoate | - |
Lithospermum erythrorhizon | |
| 0.0459 | - |
geranyl diphosphate | - |
Lithospermum erythrorhizon | |
| 0.0538 | - |
4-hydroxybenzoate | - |
Lithospermum erythrorhizon | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| geranyl diphosphate + 4-hydroxybenzoate | Lithospermum erythrorhizon | - |
3-geranyl-4-hydroxybenzoate + diphosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lithospermum erythrorhizon | Q8W404 | - |
- |
| Lithospermum erythrorhizon | Q8W405 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| root | the mRNA of the LePGT-1 gene is undetectable in aerial plant tissues, and is exclusively detected in root tissues, similar to shikonin accumulation | Lithospermum erythrorhizon | - |
| root | the mRNA of the LePGT-2 gene is undetectable in aerial plant tissues, and is exclusively detected in root tissues, similar to shikonin accumulation | Lithospermum erythrorhizon | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| geranyl diphosphate + 4-hydroxybenzoate | - |
Lithospermum erythrorhizon | 3-geranyl-4-hydroxybenzoate + diphosphate | - |
? | |
| geranyl diphosphate + 4-hydroxybenzoate | the enzyme accepts only geranyl diphosphate and not dimethylallyl diphosphate, farnesyl diphosphate, or geranylgeranyl diphosphate as the substrate | Lithospermum erythrorhizon | 3-geranyl-4-hydroxybenzoate + diphosphate | - |
? | |
| geranyl diphosphate + 4-hydroxybenzoate | the enzyme accepts only geranyl-diphosphate and not dimethylallyl diphosphate, farnesyl diphosphate, or geranylgeranyl diphosphate as the substrate | Lithospermum erythrorhizon | 3-geranyl-4-hydroxybenzoate + diphosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 4HB:geranyltransferase | - |
Lithospermum erythrorhizon |
| geranyl diphosphate:4-hydroxybenzoate geranyltransferase | - |
Lithospermum erythrorhizon |
| LePGT-1 | - |
Lithospermum erythrorhizon |
| LePGT-2 | - |
Lithospermum erythrorhizon |
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Release 2023.1 (January 2023)
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