Cloned (Comment) | Organism |
---|---|
expression as glutathione-S-transferase fusion protein | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
nerolidol | competitive, 57% inhibition at 50 nM | Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0011 | - |
(2E,6E)-farnesyl diphosphate | pH 7.5, 30°C | Plasmodium falciparum | |
0.0024 | - |
isopentenyl diphosphate | pH 7.5, 30°C | Plasmodium falciparum |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
63000 | - |
x * 63000, SDS-PAGE of recombinant enzyme | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | O96130 | - |
- |
Purification (Comment) | Organism |
---|---|
partial, from schizont stage parasite | Plasmodium falciparum |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
schizont | - |
Plasmodium falciparum | - |
trophozoite | - |
Plasmodium falciparum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate | - |
Plasmodium falciparum | 5 diphosphate + all-trans-octaprenyl diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + 6 isopentenyl diphosphate | - |
Plasmodium falciparum | 6 diphosphate + all-trans-nonaprenyl diphosphate | - |
? | |
additional information | no substrate: geranyl diphosphate, geranylgeranyl diphosphate | Plasmodium falciparum | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 63000, SDS-PAGE of recombinant enzyme | Plasmodium falciparum |
Synonyms | Comment | Organism |
---|---|---|
octaprenyl pyrophosphate synthase | - |
Plasmodium falciparum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000015 | - |
nerolidol | pH 7.5, 30°C | Plasmodium falciparum |