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Literature summary for 2.5.1.86 extracted from

  • Wang, W.; Dong, C.; McNeil, M.; Kaur, D.; Mahapatra, S.; Crick, D.C.; Naismith, J.H.
    The structural basis of chain length control in Rv1086 (2008), J. Mol. Biol., 381, 129-140.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
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Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment) Organism
crystallization using sparse matrix screens and vapor diffusion, structures of Rv2361c in the apo form, with isopentyl diphosphate bound and with a substrate analogue, citronellyl diphosphate Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate Mycobacterium tuberculosis the enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan 7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate Mycobacterium tuberculosis H37Rv the enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan 7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
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?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WFF7
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-
Mycobacterium tuberculosis H37Rv P9WFF7
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-

Reaction

Reaction Comment Organism Reaction ID
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + trans,octacis-decaprenyl diphosphate mechanism: 1. the C5 unit of isopentenyl diphosphate adds to the a-end of the polyisoprene polymer, 2. in processive enzymes such as Rv2361c, the nascent chain (C15 to C45) moves to the polymer site displacing the diphosphate, 3. the empty isopentenyl diphosphate site is then reloaded and another C5 unit is added in an iterative fashion until the physiologically relevant chain length is generated Mycobacterium tuberculosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
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Mycobacterium tuberculosis 7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate the enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan Mycobacterium tuberculosis 7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate
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Mycobacterium tuberculosis H37Rv 7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
-
?
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate the enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan Mycobacterium tuberculosis H37Rv 7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate
-
?

Subunits

Subunits Comment Organism
dimer crystal structure suggests that Rv2361c is a dimer Mycobacterium tuberculosis

Synonyms

Synonyms Comment Organism
Rv2361c
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Mycobacterium tuberculosis