Cloned (Comment) | Organism |
---|---|
- |
Mycobacterium tuberculosis |
Crystallization (Comment) | Organism |
---|---|
crystallization using sparse matrix screens and vapor diffusion, structures of Rv2361c in the apo form, with isopentyl diphosphate bound and with a substrate analogue, citronellyl diphosphate | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate | Mycobacterium tuberculosis | the enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan | 7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate | - |
? | |
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate | Mycobacterium tuberculosis H37Rv | the enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan | 7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WFF7 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WFF7 | - |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + trans,octacis-decaprenyl diphosphate | mechanism: 1. the C5 unit of isopentenyl diphosphate adds to the a-end of the polyisoprene polymer, 2. in processive enzymes such as Rv2361c, the nascent chain (C15 to C45) moves to the polymer site displacing the diphosphate, 3. the empty isopentenyl diphosphate site is then reloaded and another C5 unit is added in an iterative fashion until the physiologically relevant chain length is generated | Mycobacterium tuberculosis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate | - |
Mycobacterium tuberculosis | 7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate | - |
? | |
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate | the enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan | Mycobacterium tuberculosis | 7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate | - |
? | |
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate | - |
Mycobacterium tuberculosis H37Rv | 7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate | - |
? | |
(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate | the enzyme is involved in the biosynthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of essential mycobacterial cell wall components, such as the mycolyl-arabinogalactan-peptidoglycan complex and lipoarabinomannan | Mycobacterium tuberculosis H37Rv | 7 diphosphate + (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | crystal structure suggests that Rv2361c is a dimer | Mycobacterium tuberculosis |
Synonyms | Comment | Organism |
---|---|---|
Rv2361c | - |
Mycobacterium tuberculosis |