Cloned (Comment) | Organism |
---|---|
expression of beta60 capsid carying lumazine synthase activity | Bacillus subtilis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-(4-phosphonobutyryl)amino-6-D-ribitylaminouracil | comparison with inhibition of Escherichia coli riboflavin synthase | Bacillus subtilis | |
5-(5-phosphonopentyl)amino-6-D-ribitylaminouracil | comparison with inhibition of Escherichia coli riboflavin synthase | Bacillus subtilis | |
5-(5-phosphonoxyvaleryl)amino-6-D-ribitylaminouracil | mixed inhibition, comparison with inhibition of Escherichia coli riboflavin synthase | Bacillus subtilis | |
5-(hexyl 6-dihydrogen phosphate)-6-([(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]amino)pyrimidine-2,4(1H,3H)-dione | mixed inhibition, comparison with inhibition of Escherichia coli riboflavin synthase | Bacillus subtilis | |
additional information | incorporation of an amide into 5-phosphonoalkyl-6-D-ribitylaminopyrimidinedione lumazine synthase inhibitors results in an unexpected reversal of selectivity for riboflavin synthase versus lumazine synthase | Bacillus subtilis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus subtilis | - |
lumazine synthase/riboflavin synthase complex | - |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Bacillus subtilis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Bacillus subtilis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.13 | - |
5-(hexyl 6-dihydrogen phosphate)-6-([(2S,3S,4R)-2,3,4,5-tetrahydroxypentyl]amino)pyrimidine-2,4(1H,3H)-dione | pH 7.5, 37°C, recombinant beta60 capsid | Bacillus subtilis | |
0.83 | - |
5-(5-phosphonoxyvaleryl)amino-6-D-ribitylaminouracil | pH 7.5, 37°C, recombinant beta60 capsid | Bacillus subtilis | |
0.86 | - |
5-(4-phosphonobutyryl)amino-6-D-ribitylaminouracil | pH 7.5, 37°C, recombinant beta60 capsid | Bacillus subtilis | |
1 | - |
5-(5-phosphonopentyl)amino-6-D-ribitylaminouracil | pH 7.5, 37°C, recombinant beta60 capsid | Bacillus subtilis |