Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4,5-dithiohydroxyphthalic acid | structural analogue of the 5-hydroxy-4,5-dihydropyridine-2,3-dicarboxylic acid intermediate. Compound coordinates to the enzyme [4Fe-4S] cluster through a differentiated iron site, thus leading to the inhibition of quinolate formation. Compound is inhibitory in vitro and in vivo | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
NadA | - |
Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
4Fe-4S-center | inhibitor 4,5-dithiohydroxyphthalic acid coordinates to the enzyme [4Fe-4S] cluster through a differentiated iron site | Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.007 | - |
pH not specified in the publication, temperature not specified in the publication | Escherichia coli | 4,5-dithiohydroxyphthalic acid |