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Literature summary for 2.5.1.7 extracted from
- Inhibitors of the peptidoglycan biosynthesis enzymes MurA-F (2014), Bioorg. Chem., 55, 2-15.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (+/-)-tulipaline B | - |
Escherichia coli |  |
| 2-(4-methylpiperazin-1-yl)-3,4-dihydronaphthalen-1(2H)-one | - |
Escherichia coli | |
| 2-bromo-5-[(Z)-2-bromo-2-nitroethenyl]furan | - |
Escherichia coli | |
| 4,7-dichloro-5-hydroxy-1,3-benzoxathiol-2-one | - |
Escherichia coli | |
| 7-chloro-6-(4-hydroxyphenoxy)quinoline-5,8-dione | - |
Escherichia coli | |
| cnicin | - |
Escherichia coli | |
| Cpd1 | - |
Escherichia coli | |
| ebselen | - |
Escherichia coli | |
| fosfomycin | irreversible inhibition | Escherichia coli | |
| HESFWYLPHHQSY | competitive inhibition | Escherichia coli | |
| RWJ-3981 | - |
Escherichia coli | |
| T6361 | - |
Escherichia coli | |
| terreic acid | - |
Escherichia coli | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Escherichia coli | 5737 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine | Escherichia coli | - |
phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine | - |
Escherichia coli | phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MurA | - |
Escherichia coli |
| UDP-N-acetylglucosamine 1-carboxyvinyl-transferase | - |
Escherichia coli |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0002 | - |
pH and temperature not specified in the publication | Escherichia coli | RWJ-3981 | |
| 0.00028 | - |
pH and temperature not specified in the publication | Escherichia coli | 4,7-dichloro-5-hydroxy-1,3-benzoxathiol-2-one | |
| 0.002 | - |
pH and temperature not specified in the publication | Escherichia coli | (+/-)-tulipaline B | |
| 0.0028 | - |
pH and temperature not specified in the publication | Escherichia coli | 2-bromo-5-[(Z)-2-bromo-2-nitroethenyl]furan | |
| 0.006 | - |
pH and temperature not specified in the publication | Escherichia coli | Cpd1 | |
| 0.00853 | - |
pH and temperature not specified in the publication | Escherichia coli | 2-(4-methylpiperazin-1-yl)-3,4-dihydronaphthalen-1(2H)-one | |
| 0.0088 | - |
pH and temperature not specified in the publication | Escherichia coli | fosfomycin | |
| 0.0103 | - |
pH and temperature not specified in the publication | Escherichia coli | cnicin | |
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