Cloned (Comment) | Organism |
---|---|
- |
Staphylococcus aureus |
- |
Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-oxo-1,3-benzoxathiol-5-yl (3-chlorophenyl)carbamate | - |
Escherichia coli | |
2-oxo-1,3-benzoxathiol-5-yl (3-chlorophenyl)carbamate | - |
Staphylococcus aureus | |
2-oxo-1,3-benzoxathiol-5-yl methylcarbamate | - |
Escherichia coli | |
2-oxo-1,3-benzoxathiol-5-yl methylcarbamate | - |
Staphylococcus aureus | |
2-oxo-1,3-benzoxathiol-5-yl pyridine-4-carboxylate | - |
Escherichia coli | |
2-oxo-1,3-benzoxathiol-5-yl pyridine-4-carboxylate | - |
Staphylococcus aureus | |
2-oxo-1,3-benzoxathiol-6-yl 4-nitrobenzenesulfonate | - |
Escherichia coli | |
2-oxo-1,3-benzoxathiol-6-yl 4-nitrobenzenesulfonate | - |
Staphylococcus aureus | |
2-oxo-1,3-benzoxathiol-6-yl benzenesulfonate | - |
Escherichia coli | |
2-oxo-1,3-benzoxathiol-6-yl benzenesulfonate | - |
Staphylococcus aureus | |
2-oxo-1,3-benzoxathiol-6-yl methanesulfonate | - |
Escherichia coli | |
2-oxo-1,3-benzoxathiol-6-yl methanesulfonate | - |
Staphylococcus aureus | |
2-oxo-1,3-benzoxathiol-6-yl sulfamate | - |
Escherichia coli | |
2-oxo-1,3-benzoxathiol-6-yl sulfamate | - |
Staphylococcus aureus | |
4,7-dichloro-5-hydroxy-1,3-benzoxathiol-2-one | - |
Escherichia coli | |
4,7-dichloro-5-hydroxy-1,3-benzoxathiol-2-one | - |
Staphylococcus aureus | |
5,7-dibromo-6-hydroxy-1,3-benzoxathiol-2-one | - |
Escherichia coli | |
5,7-dibromo-6-hydroxy-1,3-benzoxathiol-2-one | - |
Staphylococcus aureus | |
5-(prop-2-en-1-yloxy)-1,3-benzoxathiol-2-one | - |
Escherichia coli | |
5-(prop-2-en-1-yloxy)-1,3-benzoxathiol-2-one | - |
Staphylococcus aureus | |
5-hydroxy-7-(3-methylphenyl)-1,3-benzoxathiol-2-one | - |
Escherichia coli | |
5-hydroxy-7-(3-methylphenyl)-1,3-benzoxathiol-2-one | slight inhibition at 0.12 mM | Staphylococcus aureus | |
5-hydroxy-7-(4-methoxyphenyl)-1,3-benzoxathiol-2-one | - |
Escherichia coli | |
5-hydroxy-7-(4-methoxyphenyl)-1,3-benzoxathiol-2-one | slight inhibition at 0.12 mM | Staphylococcus aureus | |
5-hydroxybenzo[d][1,3]oxathiol-2-one | - |
Escherichia coli | |
5-hydroxybenzo[d][1,3]oxathiol-2-one | - |
Staphylococcus aureus | |
5-hydroxynaphtho[1,2-d][1,3]oxathiol-2-one | - |
Escherichia coli | |
5-hydroxynaphtho[1,2-d][1,3]oxathiol-2-one | - |
Staphylococcus aureus | |
5-hydroxynaphtho[2,1-d][1,3]oxathiol-2-one | - |
Escherichia coli | |
5-hydroxynaphtho[2,1-d][1,3]oxathiol-2-one | - |
Staphylococcus aureus | |
5-methoxy-1,3-benzoxathiole | - |
Escherichia coli | |
5-methoxy-1,3-benzoxathiole | slight inhibition at 0.12 mM | Staphylococcus aureus | |
5-methoxybenzo[d][1,3]oxathiol-2-one | - |
Escherichia coli | |
5-methoxybenzo[d][1,3]oxathiol-2-one | - |
Staphylococcus aureus | |
7-(4-fluorophenyl)-5-hydroxy-1,3-benzoxathiol-2-one | - |
Escherichia coli | |
7-(4-fluorophenyl)-5-hydroxy-1,3-benzoxathiol-2-one | slight inhibition at 0.12 mM | Staphylococcus aureus | |
fosfomycin | - |
Escherichia coli | |
fosfomycin | - |
Staphylococcus aureus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Escherichia coli JM109 | - |
- |
- |
Staphylococcus aureus | - |
- |
- |
Staphylococcus aureus SH1000 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | - |
Staphylococcus aureus | UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + phosphate | - |
r | |
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | - |
Escherichia coli | UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + phosphate | - |
r | |
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | - |
Escherichia coli JM109 | UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + phosphate | - |
r | |
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine | - |
Staphylococcus aureus SH1000 | UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + phosphate | - |
r |
Synonyms | Comment | Organism |
---|---|---|
MurA | - |
Staphylococcus aureus |
MurA | - |
Escherichia coli |
UDP-N-acetylglucosamine enolpyruvyl transferase | - |
Staphylococcus aureus |
UDP-N-acetylglucosamine enolpyruvyl transferase | - |
Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00025 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | 2-oxo-1,3-benzoxathiol-6-yl sulfamate | |
0.00028 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | 4,7-dichloro-5-hydroxy-1,3-benzoxathiol-2-one | |
0.00046 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Staphylococcus aureus | 2-oxo-1,3-benzoxathiol-5-yl methylcarbamate | |
0.00046 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | 2-oxo-1,3-benzoxathiol-5-yl methylcarbamate | |
0.00053 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | 5-hydroxybenzo[d][1,3]oxathiol-2-one | |
0.00058 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Staphylococcus aureus | 2-oxo-1,3-benzoxathiol-5-yl pyridine-4-carboxylate | |
0.00058 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | 2-oxo-1,3-benzoxathiol-5-yl pyridine-4-carboxylate | |
0.0006 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | fosfomycin | |
0.00076 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | 2-oxo-1,3-benzoxathiol-6-yl methanesulfonate | |
0.00095 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | 5,7-dibromo-6-hydroxy-1,3-benzoxathiol-2-one | |
0.00109 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Staphylococcus aureus | 4,7-dichloro-5-hydroxy-1,3-benzoxathiol-2-one | |
0.00113 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Staphylococcus aureus | 2-oxo-1,3-benzoxathiol-6-yl methanesulfonate | |
0.00125 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Staphylococcus aureus | fosfomycin | |
0.00155 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | 5-hydroxynaphtho[2,1-d][1,3]oxathiol-2-one | |
0.00196 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | 2-oxo-1,3-benzoxathiol-6-yl benzenesulfonate | |
0.00239 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Staphylococcus aureus | 2-oxo-1,3-benzoxathiol-6-yl sulfamate | |
0.00243 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | 2-oxo-1,3-benzoxathiol-6-yl sulfamate | |
0.00286 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Staphylococcus aureus | 2-oxo-1,3-benzoxathiol-5-yl (3-chlorophenyl)carbamate | |
0.00286 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | 2-oxo-1,3-benzoxathiol-5-yl (3-chlorophenyl)carbamate | |
0.0031 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | 5-hydroxynaphtho[1,2-d][1,3]oxathiol-2-one | |
0.00349 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Staphylococcus aureus | 5,7-dibromo-6-hydroxy-1,3-benzoxathiol-2-one | |
0.00515 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | 2-oxo-1,3-benzoxathiol-6-yl 4-nitrobenzenesulfonate | |
0.00645 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | 5-methoxybenzo[d][1,3]oxathiol-2-one | |
0.00668 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Staphylococcus aureus | 2-oxo-1,3-benzoxathiol-6-yl benzenesulfonate | |
0.00727 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | 5-hydroxy-7-(3-methylphenyl)-1,3-benzoxathiol-2-one | |
0.00801 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Staphylococcus aureus | 5-(prop-2-en-1-yloxy)-1,3-benzoxathiol-2-one | |
0.00801 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | 5-(prop-2-en-1-yloxy)-1,3-benzoxathiol-2-one | |
0.00951 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | 5-hydroxy-7-(4-methoxyphenyl)-1,3-benzoxathiol-2-one | |
0.01079 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Staphylococcus aureus | 2-oxo-1,3-benzoxathiol-6-yl 4-nitrobenzenesulfonate | |
0.01428 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | 5-methoxy-1,3-benzoxathiole | |
0.01794 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Staphylococcus aureus | 2-oxo-1,3-benzoxathiol-6-yl sulfamate | |
0.01854 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Escherichia coli | 7-(4-fluorophenyl)-5-hydroxy-1,3-benzoxathiol-2-one | |
0.02431 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Staphylococcus aureus | 5-hydroxynaphtho[1,2-d][1,3]oxathiol-2-one | |
0.02479 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Staphylococcus aureus | 5-methoxybenzo[d][1,3]oxathiol-2-one | |
0.02609 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Staphylococcus aureus | 5-hydroxynaphtho[2,1-d][1,3]oxathiol-2-one | |
0.02707 | - |
in 50 mM Tris-HCl, pH 7.9, at 37°C | Staphylococcus aureus | 5-hydroxybenzo[d][1,3]oxathiol-2-one |