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Literature summary for 2.5.1.7 extracted from

  • Venkateswaran, P.S.; Lugtenberg, E.J.J.; Wu, H.C.
    Inhibition of phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase by uridine diphosphate N-acetylmuramyl peptides (1973), Biochim. Biophys. Acta, 293, 570-574.
    View publication on PubMed
Search for more literature for 2.5.1.7

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by UDP-galactose Escherichia coli
phosphonomycin i.e. L-cis-2-epoxypropylphosphonic acid; inhibitor binding site is distinct from active site; irreversible inactivation, requires the presence of UDP-GlcNAc Escherichia coli
UDP-N-acetylmuramic acid weak Escherichia coli
UDP-N-acetylmuramic acid-L-Ala weak Escherichia coli
UDP-N-acetylmuramic acid-L-Ala-D-Glu weak Escherichia coli
UDP-N-acetylmuramyl-L-Ala-D-Glu-meso-alpha,epsilon-diaminopimelic acid
-
 Bacillus cereus
UDP-N-acetylmuramyl-L-Ala-D-Glu-meso-alpha,epsilon-diaminopimelic acid above 1 mM Escherichia coli
uridine diphospho-N-acetylmuramyl-L-Ala-D-gamma-Glu-meso-alpha,epsilon-diaminopimelic-acid-D-Ala-D-Ala
-
 Bacillus cereus
uridine diphospho-N-acetylmuramyl-L-Ala-D-gamma-Glu-meso-alpha,epsilon-diaminopimelic-acid-D-Ala-D-Ala above 1 mM Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine Escherichia coli pathway for biosynthesis of UDP-N-acetylmuramic acid phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
-
 ?
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine Escherichia coli K-235 pathway for biosynthesis of UDP-N-acetylmuramic acid phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus cereus
-
-
-
Bacillus cereus T
-
-
-
Escherichia coli
-
-
-
Escherichia coli
-
 K-12 strain KMBL-146
-
Escherichia coli K-235
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine
-
 Escherichia coli phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine i.e. UDP-N-acetyl-D-glucosamine-enolpyruvate ?
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine
-
 Bacillus cereus phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine i.e. UDP-N-acetyl-D-glucosamine-enolpyruvate ?
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine pathway for biosynthesis of UDP-N-acetylmuramic acid Escherichia coli phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
-
 ?
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine
-
 Escherichia coli K-235 phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine i.e. UDP-N-acetyl-D-glucosamine-enolpyruvate ?
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine pathway for biosynthesis of UDP-N-acetylmuramic acid Escherichia coli K-235 phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
-
 ?
phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine
-
 Bacillus cereus T phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine i.e. UDP-N-acetyl-D-glucosamine-enolpyruvate ?