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Literature summary for 2.5.1.63 extracted from

  • Deng, H.; Cobb, S.L.; Gee, A.D.; Lockhart, A.; Martarello, L.; McGlinchey, R.P.; OHagan, D.; Onega, M.
    Fluorinase mediated C-18F bond formation, an enzymatic tool for PET labelling (2006), Chem. Commun. (Camb. ), 2006, 652-654.
No PubMed abstract available
Search for more literature for 2.5.1.63

Application

Application Comment Organism
analysis the fluorinase enzyme from Streptomyces cattleya is applied as a catalyst for the efficient incorporation of [18F]-fluoride into [18F]-59-fluoro-59-deoxyadenosine, [18F]-59-fluoro-59-deoxyinosine and [18F]-5-fluoro-5-deoxyribose for positron emission tomography, PET, applications, useful for imaging tumors, monitoring the distribution of drugs and identifying cell and receptor degeneration in the brain, coupled enzyme system, overview Streptomyces cattleya

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
S-adenosyl-L-methionine + fluoride Streptomyces cattleya
-
 5'-deoxy-5'-fluoroadenosine + L-methionine
-
 ?

Organism

Organism UniProt Comment Textmining
Streptomyces cattleya
-
-
-

Reaction

Reaction Comment Organism Reaction ID
S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine C-F bond formation, the enzyme catalyses an SN2 type reaction mechanism Streptomyces cattleya
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information fluorinase coupled enzyme systems for the synthesis of various 18F-labelled compounds, overview Streptomyces cattleya ?
-
 ?
S-adenosyl-L-methionine + fluoride
-
 Streptomyces cattleya 5'-deoxy-5'-fluoroadenosine + L-methionine
-
 ?
S-adenosyl-L-methionine + fluoride C-F bond formation, the enzyme catalyses an SN2 type reaction mechanism Streptomyces cattleya 5'-deoxy-5'-fluoroadenosine + L-methionine
-
 ?

Synonyms

Synonyms Comment Organism
5'-FDAS
-
 Streptomyces cattleya
5'-fluoro-5'-deoxyadenosine synthase
-
 Streptomyces cattleya
fluorinase
-
 Streptomyces cattleya