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Literature summary for 2.5.1.61 extracted from
- Purification and some properties of rat liver uroporphyrinogen I synthase (1988), Anal. Asoc. Quim. Argent., 76, 207-215.
No PubMed abstract available
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NH4+ | - |
Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.017 | - |
porphobilinogen | 0.1 M phosphate buffer, pH 7.5 | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 41000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | third enzyme in the heme biosynthetic pathway | ? | - |
? | |
| additional information | Rattus norvegicus | third enzyme in the heme biosynthetic pathway | ? | - |
? | |
| porphobilinogen | Escherichia coli | - |
? | - |
? | |
| porphobilinogen | Homo sapiens | - |
? | - |
? | |
| porphobilinogen | Rattus norvegicus | - |
? | - |
? | |
| porphobilinogen | Spinacia oleracea | - |
? | - |
? | |
| porphobilinogen | Chlorella regularis | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Chlorella regularis | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
Wistar albino rat | - |
| Spinacia oleracea | - |
spinach | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4 porphobilinogen | in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 | Escherichia coli | uroporphyrinogen III + 4 NH3 | - |
? | |
| 4 porphobilinogen | in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 | Homo sapiens | uroporphyrinogen III + 4 NH3 | - |
? | |
| 4 porphobilinogen | in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 | Rattus norvegicus | uroporphyrinogen III + 4 NH3 | - |
? | |
| 4 porphobilinogen | in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 | Spinacia oleracea | uroporphyrinogen III + 4 NH3 | - |
? | |
| 4 porphobilinogen | in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 | Chlorella regularis | uroporphyrinogen III + 4 NH3 | - |
? | |
| 4 porphobilinogen + H2O | - |
Escherichia coli | hydroxylmethylbilane + 4 NH3 | - |
? | |
| 4 porphobilinogen + H2O | - |
Homo sapiens | hydroxylmethylbilane + 4 NH3 | - |
? | |
| 4 porphobilinogen + H2O | - |
Rattus norvegicus | hydroxylmethylbilane + 4 NH3 | - |
? | |
| 4 porphobilinogen + H2O | - |
Spinacia oleracea | hydroxylmethylbilane + 4 NH3 | - |
? | |
| 4 porphobilinogen + H2O | - |
Chlorella regularis | hydroxylmethylbilane + 4 NH3 | - |
? | |
| additional information | third enzyme in the heme biosynthetic pathway | Homo sapiens | ? | - |
? | |
| additional information | third enzyme in the heme biosynthetic pathway | Rattus norvegicus | ? | - |
? | |
| porphobilinogen | - |
Escherichia coli | ? | - |
? | |
| porphobilinogen | - |
Homo sapiens | ? | - |
? | |
| porphobilinogen | - |
Rattus norvegicus | ? | - |
? | |
| porphobilinogen | - |
Spinacia oleracea | ? | - |
? | |
| porphobilinogen | - |
Chlorella regularis | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HMB-S | - |
Escherichia coli |
| HMB-S | - |
Homo sapiens |
| HMB-S | - |
Rattus norvegicus |
| porphobilinogen deaminase | - |
Escherichia coli |
| porphobilinogen deaminase | - |
Homo sapiens |
| porphobilinogen deaminase | - |
Rattus norvegicus |
| URO-S | - |
Rattus norvegicus |
| uroporphyrinogen I synthase | - |
Homo sapiens |
| uroporphyrinogen I synthase | - |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
at 37°C | Rattus norvegicus |
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