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Literature summary for 2.5.1.60 extracted from

  • Koehnke, M.; Delon, C.; Hastie, M.L.; Nguyen, U.T.; Wu, Y.W.; Waldmann, H.; Goody, R.S.; Gorman, J.J.; Alexandrov, K.
    Rab GTPase prenylation hierarchy and its potential role in choroideremia disease (2013), PLoS ONE, 8, e81758.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.60

Activating Compound

Activating Compound Comment Organism Structure
Rab escort protein REP, unlike the other prenyltransferases, farnesyl-transferase and geranylgeranyl-transferase I (GGTaseI), RabGGTase does not rely on a consensus sequence such as the CAAX box, but instead has delegated substrate recognition to a third protein, the Rab escort protein Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens unlike the other prenyltransferases, farnesyl-transferase and geranylgeranyl-transferase I (GGTaseI), RabGGTase does not rely on a consensus sequence such as the CAAX box, but instead has delegated substrate recognition to a third protein, the Rab escort protein (REP) ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
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 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information unlike the other prenyltransferases, farnesyl-transferase and geranylgeranyl-transferase I (GGTaseI), RabGGTase does not rely on a consensus sequence such as the CAAX box, but instead has delegated substrate recognition to a third protein, the Rab escort protein (REP) Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Rab geranylgeranyl-transferase
-
 Homo sapiens
RabGGTase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction underprenylation of RabGTPases causes choroideremia, which is a rare genetic disease, affecting 4% of theblind population. It is due to mutation/lack of activity of the Rab escort protein,REP, while the activity of the Rab geranylgeranyl-transferase itself is not implicated, overview Homo sapiens