Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.60 extracted from

  • Hala, M.; Elias, M.; Zarsky, V.
    A specific feature of the angiosperm Rab escort protein (REP) and evolution of the REP/GDI superfamily (2005), J. Mol. Biol., 348, 1299-1313.
    View publication on PubMed
Search for more literature for 2.5.1.60

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme is absolutely dependent on the Rab escort protein, REP, cloning and expression of His-tagged REP in Escherichia coli, and purification, overview, recombinant Arabidopsis thaliana REP-6His stimulates Rab geranylgeranylation activity in plant but not yeast cell extracts, overview Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
additional information recombinant Arabidopsis thaliana REP interacts with yeast 6His-Ypt1, tobacco 6His-RabA1a, and Arabidopsis RabA2a in vitro preferring the GDP-bound form of the latter Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Arabidopsis thaliana 5737
-
additional information subcellular localization study, overview Arabidopsis thaliana
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geranylgeranyl diphosphate + Rab protein Arabidopsis thaliana intracellular vesicular trafficking is regulated by Rab proteins, small GTPases that require posttranslational geranylgeranylation for biological activity, which is catalyzed by the enzyme, a Rab geranylgeranyl transferase in complex with the Rab escort protein, REP, overview S-geranylgeranyl-Rab protein + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
seedling
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate + Rab protein intracellular vesicular trafficking is regulated by Rab proteins, small GTPases that require posttranslational geranylgeranylation for biological activity, which is catalyzed by the enzyme, a Rab geranylgeranyl transferase in complex with the Rab escort protein, REP, overview Arabidopsis thaliana S-geranylgeranyl-Rab protein + diphosphate
-
 ?
geranylgeranyl diphosphate + Rab protein with recombinantly expressed His6-tagged Saccharomyces cerevisiae Rab GTPase Ypt1 and Nicotiana tabacum NtaRabA1a in vitro substrates, overview Arabidopsis thaliana S-geranylgeranyl-Rab protein + diphosphate
-
 ?
additional information the enzyme is complexed with the Rab escort protein, REP, recombinant Arabidopsis thaliana REP interacts with yeast 6His-Ypt1, tobacco 6His-RabA1a, and Arabidopsis RabA2a in vitro preferring the GDP-bound form of the latter, overview, enzyme activity with different REPs, wild-type and mutant REPs, and involved REP residues, overview Arabidopsis thaliana ?
-
 ?

Synonyms

Synonyms Comment Organism
Rab geranylgeranyl transferase
-
 Arabidopsis thaliana
RabGGTase
-
 Arabidopsis thaliana