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Literature summary for 2.5.1.60 extracted from

  • Zhang, H.; Seabra, M.C.; Deisenhofer, J.
    Crystal structure of Rab geranylgeranyltransferase at 2.0 Å resolution (2000), Structure Fold. Des., 8, 241-251.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
at 2.0 Angstrom resolution, the beta subunit forms an alpha-alpha barrel that contains most of the residues in the active site, the alpha subunit consists of a helical domain, an immunoglobulin-like domain and a leucine-rich repeat domain, the N-terminal alpha subunit binds to the active site in the beta subunit Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ the location of the zinc ion in the beta subunit, where it is coordinated by Asp238beta, Cys240beta and His290beta, the fourth ligand is residue His2alpha Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
geranylgeranyl diphosphate + protein-cysteine Rattus norvegicus enzyme crucial for membrane association and function of Rab proteins in intracellular vesicular trafficking S-geranylgeranyl-protein + diphosphate
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?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Reaction

Reaction Comment Organism Reaction ID
geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate mechanism Rattus norvegicus
geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate enzyme is unique in the protein prenyltransferase family, consisting protein farnesyltransferase, EC 2.5.1.58, protein geranylgeranyltransferase type I, EC 2.5.1.59 and Rab geranylgeranyltransferase Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate + protein-cysteine
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Rattus norvegicus S-geranylgeranyl-protein + diphosphate
-
?
geranylgeranyl diphosphate + protein-cysteine enzyme crucial for membrane association and function of Rab proteins in intracellular vesicular trafficking Rattus norvegicus S-geranylgeranyl-protein + diphosphate
-
?