Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-methionine + H2O | Homo sapiens | the enzyme is involved in S-adenosylmethionine synthesis in liver | phosphate + diphosphate + S-adenosyl-L-methionine | - |
? | |
ATP + L-methionine + H2O | Mus musculus | the enzyme is involved in S-adenosylmethionine synthesis in liver | phosphate + diphosphate + S-adenosyl-L-methionine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q00266 | - |
- |
Mus musculus | Q91X83 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-methionine + H2O | - |
Homo sapiens | phosphate + diphosphate + S-adenosyl-L-methionine | - |
? | |
ATP + L-methionine + H2O | - |
Mus musculus | phosphate + diphosphate + S-adenosyl-L-methionine | - |
? | |
ATP + L-methionine + H2O | the enzyme is involved in S-adenosylmethionine synthesis in liver | Homo sapiens | phosphate + diphosphate + S-adenosyl-L-methionine | - |
? | |
ATP + L-methionine + H2O | the enzyme is involved in S-adenosylmethionine synthesis in liver | Mus musculus | phosphate + diphosphate + S-adenosyl-L-methionine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAT1A | - |
Homo sapiens |
MAT1A | - |
Mus musculus |
MATalpha1 | - |
Homo sapiens |
MATalpha1 | - |
Mus musculus |
methionine adenosyltransferase alpha1 | - |
Homo sapiens |
methionine adenosyltransferase alpha1 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | MAT1A expression falls in hepatocytes and bile duct epithelial cells during chronic cholestasis and in human cholangiocarcinoma | up |
Mus musculus | MAT1A expression falls in hepatocytes and bile duct epithelial cells during chronic cholestasis and in murine cholangiocarcinoma | up |
General Information | Comment | Organism |
---|---|---|
malfunction | knocking down MAT1A or overexpressing MafG or c-Maf enhances cholangiocarcinoma growth and invasion in vivo | Homo sapiens |
malfunction | knocking down MAT1A or overexpressing MafG or c-Maf enhances cholangiocarcinoma growth and invasion in vivo | Mus musculus |
metabolism | the enzyme is involved in S-adenosylmethionine synthesis in liver. MATalpha1 interacts mainly with Mnt in normal liver but this switches to c-Maf, MafG and c-Myc in cholestatic livers and cholangiocarcinoma. Knocking down MAT1A or overexpressing MafG or c-Maf enhances cholangiocarcinoma growth and invasion in vivo | Homo sapiens |
metabolism | the enzyme is involved in S-adenosylmethionine synthesis in liver. MATalpha1 interacts mainly with Mnt in normal liver but this switches to c-Maf, MafG and c-Myc in cholestatic livers and cholangiocarcinoma. Knocking down MAT1A or overexpressing MafG or c-Maf enhances cholangiocarcinoma growth and invasion in vivo | Mus musculus |