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Literature summary for 2.5.1.6 extracted from

  • Yang, H.; Liu, T.; Wang, J.; Li, T.W.; Fan, W.; Peng, H.; Krishnan, A.; Gores, G.J.; Mato, J.M.; Lu, S.C.
    Deregulated methionine adenosyltransferase alpha1, c-Myc, and Maf proteins together promote cholangiocarcinoma growth in mice and humans (2016), Hepatology, 64, 439-455 .
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-methionine + H2O Homo sapiens the enzyme is involved in S-adenosylmethionine synthesis in liver phosphate + diphosphate + S-adenosyl-L-methionine
-
?
ATP + L-methionine + H2O Mus musculus the enzyme is involved in S-adenosylmethionine synthesis in liver phosphate + diphosphate + S-adenosyl-L-methionine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q00266
-
-
Mus musculus Q91X83
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-
liver
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-methionine + H2O
-
Homo sapiens phosphate + diphosphate + S-adenosyl-L-methionine
-
?
ATP + L-methionine + H2O
-
Mus musculus phosphate + diphosphate + S-adenosyl-L-methionine
-
?
ATP + L-methionine + H2O the enzyme is involved in S-adenosylmethionine synthesis in liver Homo sapiens phosphate + diphosphate + S-adenosyl-L-methionine
-
?
ATP + L-methionine + H2O the enzyme is involved in S-adenosylmethionine synthesis in liver Mus musculus phosphate + diphosphate + S-adenosyl-L-methionine
-
?

Synonyms

Synonyms Comment Organism
MAT1A
-
Homo sapiens
MAT1A
-
Mus musculus
MATalpha1
-
Homo sapiens
MATalpha1
-
Mus musculus
methionine adenosyltransferase alpha1
-
Homo sapiens
methionine adenosyltransferase alpha1
-
Mus musculus

Expression

Organism Comment Expression
Homo sapiens MAT1A expression falls in hepatocytes and bile duct epithelial cells during chronic cholestasis and in human cholangiocarcinoma up
Mus musculus MAT1A expression falls in hepatocytes and bile duct epithelial cells during chronic cholestasis and in murine cholangiocarcinoma up

General Information

General Information Comment Organism
malfunction knocking down MAT1A or overexpressing MafG or c-Maf enhances cholangiocarcinoma growth and invasion in vivo Homo sapiens
malfunction knocking down MAT1A or overexpressing MafG or c-Maf enhances cholangiocarcinoma growth and invasion in vivo Mus musculus
metabolism the enzyme is involved in S-adenosylmethionine synthesis in liver. MATalpha1 interacts mainly with Mnt in normal liver but this switches to c-Maf, MafG and c-Myc in cholestatic livers and cholangiocarcinoma. Knocking down MAT1A or overexpressing MafG or c-Maf enhances cholangiocarcinoma growth and invasion in vivo Homo sapiens
metabolism the enzyme is involved in S-adenosylmethionine synthesis in liver. MATalpha1 interacts mainly with Mnt in normal liver but this switches to c-Maf, MafG and c-Myc in cholestatic livers and cholangiocarcinoma. Knocking down MAT1A or overexpressing MafG or c-Maf enhances cholangiocarcinoma growth and invasion in vivo Mus musculus