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Literature summary for 2.5.1.6 extracted from
- The S(MK) box is a new SAM-binding RNA for translational regulation of SAM synthetase (2006), Nat. Struct. Mol. Biol., 13, 226-233.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene metK, expression in Bacillus subtilis | Enterococcus faecalis |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | mutational analysis and structural mapping of the the S(MK) box, conserved RNA motif in the 5'-untranslated region of the metK gene, overview | Enterococcus faecalis |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| K+ | - |
Enterococcus faecalis |  |
| Mg2+ | - |
Enterococcus faecalis | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-methionine + H2O | Enterococcus faecalis | the S(MK) box, a conserved RNA motif in the 5'-untranslated region of the metK gene, is a SAM-binding RNA responsible for translational regulation of the enzyme, it binds specifically to S-adenosyl-L-methionine in vitro and in vivo causing a structural RNA rearrangement that causes a sequestration of the Shine-Dalgarno sequence, structural mapping and mechanism, overview | phosphate + diphosphate + S-adenosyl-L-methionine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Enterococcus faecalis | - |
gene metK | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + L-methionine + H2O | the S(MK) box, a conserved RNA motif in the 5'-untranslated region of the metK gene, is a SAM-binding RNA responsible for translational regulation of the enzyme, it binds specifically to S-adenosyl-L-methionine in vitro and in vivo causing a structural RNA rearrangement that causes a sequestration of the Shine-Dalgarno sequence, structural mapping and mechanism, overview | Enterococcus faecalis | phosphate + diphosphate + S-adenosyl-L-methionine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | structural mapping of the the S(MK) box, conserved RNA motif in the 5'-untranslated region of the metK gene, overview | Enterococcus faecalis |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SAM synthetase | - |
Enterococcus faecalis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Enterococcus faecalis | |
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Release 2023.1 (January 2023)
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