Literature summary for 2.5.1.6 extracted from

Gonzalez, B.; Pajares, M.A.; Hermoso, J.A.; Guillerm, D.; Guillerm, G.; Sanz-Aparicio, J.
Crystal structures of methionine adenosyltransferase complexed with substrates and products reveal the methionine-ATP recognition and give insights into the catalytic mechanism (2003), J. Mol. Biol., 331, 407-416.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with inhibitor (2S,4S)-amino-4,5-epoxypentanoic acid	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
(2S,4S)-amino-4,5-epoxypentanoic acid	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P13444	tetrameric form MAT I	-

Reaction

Reaction	Comment	Organism	Reaction ID
ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine	mechanism, key role of K182 in the correct positioning of the substrates, and D135 in stabilizing the sulfonium group formed in the product	Rattus norvegicus	a

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Release 2023.1 (January 2023)