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Literature summary for 2.5.1.6 extracted from

  • Geller, A.M.; Kotb, M.Y.S.; Jernigan, H.M.; Kredich, N.M.
    Purification and properties of rat lens methionine adenosyltransferase (1986), Exp. Eye Res., 43, 997-1008.
    View publication on PubMed
Search for more literature for 2.5.1.6

Inhibitors

Inhibitors Comment Organism Structure
Dimethylsulfoxide
-
 Rattus norvegicus
diphosphate individually a weak inhibitor, in combination with phosphate there is a marked synergistic effect Rattus norvegicus
K+ above 50 mM Rattus norvegicus
phosphate individually a weak inhibitor, in combination with diphosphate there is a synergistic inhibitory effect Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.08
-
 ATP
-
 Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
K+ activation at 25-50 mM Rattus norvegicus
Mg2+ optimal concentration at 10-20 mM Rattus norvegicus
Mn2+ optimal concentration at 2 mM Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-methionine + H2O Rattus norvegicus
-
 S-adenosyl-L-methionine + phosphate + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2'-deoxy-ATP + L-methionine + H2O
-
 Rattus norvegicus ?
-
 ?
3'-deoxy-ATP + L-methionine + H2O
-
 Rattus norvegicus ?
-
 ?
ATP + L-methionine + H2O
-
 Rattus norvegicus S-adenosyl-L-methionine + phosphate + diphosphate
-
 ?