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Literature summary for 2.5.1.58 extracted from

  • Jennings, B.C.; Danowitz, A.M.; Wang, Y.C.; Gibbs, R.A.; Distefano, M.D.; Fierke, C.A.
    Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase (2016), Bioorg. Med. Chem. Lett., 26, 1333-1336.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.5.1.58

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine Rattus norvegicus
-
 S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q04631 AND Q02293 alpha-subunit and beta-subunit
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CCIQ
-
 Rattus norvegicus ?
-
 ?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CGGDD
-
 Rattus norvegicus ?
-
 ?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CSVL
-
 Rattus norvegicus ?
-
 ?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CTIQ
-
 Rattus norvegicus ?
-
 ?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CVIS
-
 Rattus norvegicus ?
-
 ?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CVLL
-
 Rattus norvegicus ?
-
 ?
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CVLS
-
 Rattus norvegicus ?
-
 ?
(2E,6E)-farnesyl diphosphate + CCIQ
-
 Rattus norvegicus S-(2E,6E)-farnesyl-CCIQ + diphosphate
-
 ?
(2E,6E)-farnesyl diphosphate + CGGDD
-
 Rattus norvegicus S-(2E,6E)-farnesyl-CGGDD + diphosphate
-
 ?
(2E,6E)-farnesyl diphosphate + CSVL
-
 Rattus norvegicus S-(2E,6E)-farnesyl-CSVL + diphosphate
-
 ?
(2E,6E)-farnesyl diphosphate + CTIQ
-
 Rattus norvegicus S-(2E,6E)-farnesyl-CTIQ + diphosphate
-
 ?
(2E,6E)-farnesyl diphosphate + CVIS
-
 Rattus norvegicus S-(2E,6E)-farnesyl-CVIS + diphosphate
-
 ?
(2E,6E)-farnesyl diphosphate + CVLL
-
 Rattus norvegicus S-(2E,6E)-farnesyl-CVLL + diphosphate
-
 ?
(2E,6E)-farnesyl diphosphate + CVLS
-
 Rattus norvegicus S-(2E,6E)-farnesyl-CVLS + diphosphate
-
 ?
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine
-
 Rattus norvegicus S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate
-
 ?
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CCIQ
-
 Rattus norvegicus ?
-
 ?
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CGGDD
-
 Rattus norvegicus ?
-
 ?
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CSVL
-
 Rattus norvegicus ?
-
 ?
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CTIQ
-
 Rattus norvegicus ?
-
 ?
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CVIS
-
 Rattus norvegicus ?
-
 ?
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CVLL
-
 Rattus norvegicus ?
-
 ?
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CVLS
-
 Rattus norvegicus ?
-
 ?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CCIQ
-
 Rattus norvegicus ?
-
 ?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CGGDD
-
 Rattus norvegicus ?
-
 ?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CSVL
-
 Rattus norvegicus ?
-
 ?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CTIQ
-
 Rattus norvegicus ?
-
 ?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CVIS
-
 Rattus norvegicus ?
-
 ?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CVLL
-
 Rattus norvegicus ?
-
 ?
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CVLS
-
 Rattus norvegicus ?
-
 ?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CCIQ
-
 Rattus norvegicus ?
-
 ?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CGGDD
-
 Rattus norvegicus ?
-
 ?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CSVL
-
 Rattus norvegicus ?
-
 ?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CTIQ
-
 Rattus norvegicus ?
-
 ?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CVIS
-
 Rattus norvegicus ?
-
 ?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CVLL
-
 Rattus norvegicus ?
-
 ?
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CVLS
-
 Rattus norvegicus ?
-
 ?
additional information analogues of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase, reactivity of four alkyne-containing analogs of farnesyl diphosphate with purified protein farnesyltransferase and a small library of dansylated peptides using an in vitro continuous spectrofluorimetric assay, overview. Activity with CGGDD, CVLL, and CSVL peptides is low with farnesyl diphosphate as well as with its analogues Rattus norvegicus ?
-
 ?

kcat/KM [mM/s]

kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
0.1
-
 CCIQ below, with (2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication Rattus norvegicus
0.1
-
 CTIQ below, with (2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication Rattus norvegicus
0.1
-
 CCIQ below, with (2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication Rattus norvegicus
1.6
-
 CVLS with (2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication Rattus norvegicus
1.8
-
 CTIQ with (2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication Rattus norvegicus
2
-
 CVLS with (2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication Rattus norvegicus
4
-
 CCIQ with (2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication Rattus norvegicus
4.9
-
 CTIQ with farnesyl diphosphate, pH and temperature not specified in the publication Rattus norvegicus
6.6
-
 CCIQ with farnesyl diphosphate, pH and temperature not specified in the publication Rattus norvegicus
10.8
-
 CVIS with (2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication Rattus norvegicus
12.1
-
 CTIQ with (2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication Rattus norvegicus
19
-
 CVLS with (2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication Rattus norvegicus
24
-
 CVLS with (2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate, pH and temperature not specified in the publication Rattus norvegicus
24
-
 CVIS with (2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate, pH and temperature not specified in the publication Rattus norvegicus
28
-
 CTIQ with (2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate, pH and temperature not specified in the publication Rattus norvegicus
32
-
 CCIQ with (2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate, pH and temperature not specified in the publication Rattus norvegicus
41
-
 CVIS with (2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication Rattus norvegicus
41
-
 CVIS with (2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication Rattus norvegicus
47
-
 CVLS with farnesyl diphosphate, pH and temperature not specified in the publication Rattus norvegicus
59
-
 CVIS with farnesyl diphosphate, pH and temperature not specified in the publication Rattus norvegicus