Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine | Rattus norvegicus | - |
S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q04631 AND Q02293 | alpha-subunit and beta-subunit | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CCIQ | - |
Rattus norvegicus | ? | - |
? | |
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CGGDD | - |
Rattus norvegicus | ? | - |
? | |
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CSVL | - |
Rattus norvegicus | ? | - |
? | |
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CTIQ | - |
Rattus norvegicus | ? | - |
? | |
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CVIS | - |
Rattus norvegicus | ? | - |
? | |
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CVLL | - |
Rattus norvegicus | ? | - |
? | |
(2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate + CVLS | - |
Rattus norvegicus | ? | - |
? | |
(2E,6E)-farnesyl diphosphate + CCIQ | - |
Rattus norvegicus | S-(2E,6E)-farnesyl-CCIQ + diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + CGGDD | - |
Rattus norvegicus | S-(2E,6E)-farnesyl-CGGDD + diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + CSVL | - |
Rattus norvegicus | S-(2E,6E)-farnesyl-CSVL + diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + CTIQ | - |
Rattus norvegicus | S-(2E,6E)-farnesyl-CTIQ + diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + CVIS | - |
Rattus norvegicus | S-(2E,6E)-farnesyl-CVIS + diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + CVLL | - |
Rattus norvegicus | S-(2E,6E)-farnesyl-CVLL + diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + CVLS | - |
Rattus norvegicus | S-(2E,6E)-farnesyl-CVLS + diphosphate | - |
? | |
(2E,6E)-farnesyl diphosphate + [protein]-L-cysteine | - |
Rattus norvegicus | S-(2E,6E)-farnesyl-[protein]-L-cysteine + diphosphate | - |
? | |
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CCIQ | - |
Rattus norvegicus | ? | - |
? | |
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CGGDD | - |
Rattus norvegicus | ? | - |
? | |
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CSVL | - |
Rattus norvegicus | ? | - |
? | |
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CTIQ | - |
Rattus norvegicus | ? | - |
? | |
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CVIS | - |
Rattus norvegicus | ? | - |
? | |
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CVLL | - |
Rattus norvegicus | ? | - |
? | |
(2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate + CVLS | - |
Rattus norvegicus | ? | - |
? | |
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CCIQ | - |
Rattus norvegicus | ? | - |
? | |
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CGGDD | - |
Rattus norvegicus | ? | - |
? | |
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CSVL | - |
Rattus norvegicus | ? | - |
? | |
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CTIQ | - |
Rattus norvegicus | ? | - |
? | |
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CVIS | - |
Rattus norvegicus | ? | - |
? | |
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CVLL | - |
Rattus norvegicus | ? | - |
? | |
(2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate + CVLS | - |
Rattus norvegicus | ? | - |
? | |
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CCIQ | - |
Rattus norvegicus | ? | - |
? | |
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CGGDD | - |
Rattus norvegicus | ? | - |
? | |
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CSVL | - |
Rattus norvegicus | ? | - |
? | |
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CTIQ | - |
Rattus norvegicus | ? | - |
? | |
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CVIS | - |
Rattus norvegicus | ? | - |
? | |
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CVLL | - |
Rattus norvegicus | ? | - |
? | |
(2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate + CVLS | - |
Rattus norvegicus | ? | - |
? | |
additional information | analogues of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase, reactivity of four alkyne-containing analogs of farnesyl diphosphate with purified protein farnesyltransferase and a small library of dansylated peptides using an in vitro continuous spectrofluorimetric assay, overview. Activity with CGGDD, CVLL, and CSVL peptides is low with farnesyl diphosphate as well as with its analogues | Rattus norvegicus | ? | - |
? |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
CCIQ | below, with (2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus | |
0.1 | - |
CTIQ | below, with (2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus | |
0.1 | - |
CCIQ | below, with (2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus | |
1.6 | - |
CVLS | with (2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus | |
1.8 | - |
CTIQ | with (2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus | |
2 | - |
CVLS | with (2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus | |
4 | - |
CCIQ | with (2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus | |
4.9 | - |
CTIQ | with farnesyl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus | |
6.6 | - |
CCIQ | with farnesyl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus | |
10.8 | - |
CVIS | with (2E,6E,10E)-3,7,11-trimethyl-12-(prop-2-yn-1-yloxy)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus | |
12.1 | - |
CTIQ | with (2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus | |
19 | - |
CVLS | with (2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus | |
24 | - |
CVLS | with (2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus | |
24 | - |
CVIS | with (2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus | |
28 | - |
CTIQ | with (2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus | |
32 | - |
CCIQ | with (2E,6E)-3,7-dimethyl-8-(prop-2-yn-1-yloxy)octa-2,6-dien-1-yl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus | |
41 | - |
CVIS | with (2E,6Z)-3,11-dimethyl-7-(prop-2-yn-1-yl)dodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus | |
41 | - |
CVIS | with (2E,6Z)-7-(but-3-yn-1-yl)-3,11-dimethyldodeca-2,6,10-trien-1-yl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus | |
47 | - |
CVLS | with farnesyl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus | |
59 | - |
CVIS | with farnesyl diphosphate, pH and temperature not specified in the publication | Rattus norvegicus |