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Literature summary for 2.5.1.58 extracted from

  • Iwasaki, S.; Omura, S.
    Search for protein farnesyltransferase inhibitors of microbial origin: our strategy and results as well as the results obtained by other groups (2007), J. Antibiot., 60, 1-12.
    View publication on PubMed
Search for more literature for 2.5.1.58

Inhibitors

Inhibitors Comment Organism Structure
10-desmethoxystreptonigrin
-
 Homo sapiens
acetylgliotoxin
-
 Homo sapiens
actinoplanic acid A
-
 Homo sapiens
actinoplanic acid B
-
 Homo sapiens
alphabeta-dehydrocurvularin
-
 Homo sapiens
andrastin A
-
 Homo sapiens
andrastin B
-
 Homo sapiens
andrastin C
-
 Homo sapiens
asukamycin
-
 Homo sapiens
barceloneic acid A
-
 Homo sapiens
chaetomellic acid A
-
 Homo sapiens
chaetomellic acid B
-
 Homo sapiens
citreohybridone A
-
 Homo sapiens
citreohybridone B
-
 Homo sapiens
clavaric acid
-
 Homo sapiens
CP-225,917
-
 Homo sapiens
CP-263,114
-
 Homo sapiens
cylindrol A
-
 Homo sapiens
cylindrol A1
-
 Homo sapiens
fusidienol
-
 Homo sapiens
fusidienol A
-
 Homo sapiens
gliotoxin
-
 Homo sapiens
granaticin A
-
 Homo sapiens
granaticin B
-
 Homo sapiens
kalafungin
-
 Homo sapiens
kampanol A
-
 Homo sapiens
kampanol B
-
 Homo sapiens
kurasoin A
-
 Homo sapiens
kurasoin B
-
 Homo sapiens
L-Cys-L-Val-L-Leu-L-Ser
-
 Homo sapiens
manumycin
-
 Homo sapiens
nanaomycin A
-
 Homo sapiens
nanaomycin D
-
 Homo sapiens
O-methylthysanone
-
 Homo sapiens
oreganic acid
-
 Homo sapiens
penicillic acid
-
 Homo sapiens
pepticinnamin A
-
 Homo sapiens
pepticinnamin B
-
 Homo sapiens
pepticinnamin C
-
 Homo sapiens
pepticinnamin D
-
 Homo sapiens
pepticinnamin E
-
 Homo sapiens
pepticinnamin F
-
 Homo sapiens
preussomerin D
-
 Homo sapiens
preussomerin G
-
 Homo sapiens
RPR113228
-
 Homo sapiens
SCH207278
-
 Homo sapiens
SCH58450
-
 Homo sapiens
sclerotiorin
-
 Homo sapiens
spiculisporic acid
-
 Homo sapiens
TAN-1813
-
 Homo sapiens
thysanone
-
 Homo sapiens
UCF116-A
-
 Homo sapiens
UCF116-B
-
 Homo sapiens
UCF76-A
-
 Homo sapiens
UCF76-B
-
 Homo sapiens
UCF76-C frenolicin B Homo sapiens
valinoctin A
-
 Homo sapiens
valinoctin B
-
 Homo sapiens
WS5995-C
-
 Homo sapiens
zaragozic acid A
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
farnesyl diphosphate + Ras oncoprotein p21
-
 Homo sapiens diphosphate + Ras-S-farnesyl oncoprotein p21
-
 ?

Synonyms

Synonyms Comment Organism
PFTase
-
 Homo sapiens
Ras protein farnesyltransferase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0001
-
-
 Homo sapiens pepticinnamin C
0.0002
-
-
 Homo sapiens pepticinnamin B
0.0003
-
-
 Homo sapiens pepticinnamin E
0.0005
-
-
 Homo sapiens pepticinnamin F
0.00065
-
-
 Homo sapiens pepticinnamin A
0.001
-
-
 Homo sapiens pepticinnamin D
0.0011
-
-
 Homo sapiens gliotoxin
0.0036
-
-
 Homo sapiens citreohybridone B
0.0044
-
-
 Homo sapiens acetylgliotoxin
0.0066
-
-
 Homo sapiens L-Cys-L-Val-L-Leu-L-Ser
0.0122
-
-
 Homo sapiens thysanone
0.0133
-
-
 Homo sapiens andrastin C
0.0145
-
-
 Homo sapiens sclerotiorin
0.0168
-
-
 Homo sapiens citreohybridone A
0.0237
-
-
 Homo sapiens O-methylthysanone
0.0249
-
-
 Homo sapiens andrastin A
0.025
-
-
 Homo sapiens penicillic acid
0.0257
-
-
 Homo sapiens WS5995-C
0.0448
-
-
 Homo sapiens granaticin B
0.0471
-
-
 Homo sapiens andrastin B
0.0473
-
-
 Homo sapiens granaticin A
0.048
-
-
 Homo sapiens spiculisporic acid
0.0487
-
-
 Homo sapiens alphabeta-dehydrocurvularin
0.058
-
-
 Homo sapiens kurasoin A
0.065
-
-
 Homo sapiens kurasoin B