Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.5.1.58 extracted from

  • Bolchi, C.; Pallavicini, M.; Rusconi, C.; Diomede, L.; Ferri, N.; Corsini, A.; Fumagalli, L.; Pedretti, A.; Vistoli, G.; Valoti, E.
    Peptidomimetic inhibitors of farnesyltransferase with high in vitro activity and significant cellular potency (2007), Bioorg. Med. Chem. Lett., 17, 6192-6196.
    View publication on PubMed
Search for more literature for 2.5.1.58

Inhibitors

Inhibitors Comment Organism Structure
N-([5-[(2R)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methoxybiphenyl-2-yl]carbonyl)-D-methionine
-
 Homo sapiens
N-([5-[(2R)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methoxybiphenyl-2-yl]carbonyl)-L-methionine
-
 Homo sapiens
N-([5-[(2R)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methylbiphenyl-2-yl]carbonyl)-D-methionine
-
 Homo sapiens
N-([5-[(2R)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methylbiphenyl-2-yl]carbonyl)-L-methionine
-
 Homo sapiens
N-([5-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methoxybiphenyl-2-yl]carbonyl)-D-methionine
-
 Homo sapiens
N-([5-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methoxybiphenyl-2-yl]carbonyl)-L-methionine
-
 Homo sapiens
N-([5-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methylbiphenyl-2-yl]carbonyl)-D-methionine
-
 Homo sapiens
N-([5-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methylbiphenyl-2-yl]carbonyl)-L-methionine
-
 Homo sapiens
N-[(5-[[(2R)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]carbamoyl]-2'-methoxybiphenyl-2-yl)carbonyl]-D-methionine
-
 Homo sapiens
N-[(5-[[(2R)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]carbamoyl]-2'-methoxybiphenyl-2-yl)carbonyl]-L-methionine
-
 Homo sapiens
N-[(5-[[(2R)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]carbamoyl]-2'-methylbiphenyl-2-yl)carbonyl]-D-methionine
-
 Homo sapiens
N-[(5-[[(2R)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]carbamoyl]-2'-methylbiphenyl-2-yl)carbonyl]-L-methionine
-
 Homo sapiens
N-[(5-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]carbamoyl]-2'-methoxybiphenyl-2-yl)carbonyl]-D-methionine
-
 Homo sapiens
N-[(5-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]carbamoyl]-2'-methoxybiphenyl-2-yl)carbonyl]-L-methionine
-
 Homo sapiens
N-[(5-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]carbamoyl]-2'-methylbiphenyl-2-yl)carbonyl]-D-methionine
-
 Homo sapiens
N-[(5-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]carbamoyl]-2'-methylbiphenyl-2-yl)carbonyl]-L-methionine
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
farnesyl diphosphate + Ras protein
-
 Homo sapiens diphosphate + S-farnesyl Ras protein
-
 ?

Synonyms

Synonyms Comment Organism
FTase
-
 Homo sapiens
Ras protein farnesyltransferase
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000045
-
-
 Homo sapiens N-([5-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methylbiphenyl-2-yl]carbonyl)-L-methionine
0.00005
-
-
 Homo sapiens N-([5-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methylbiphenyl-2-yl]carbonyl)-D-methionine
0.000053
-
-
 Homo sapiens N-([5-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methoxybiphenyl-2-yl]carbonyl)-D-methionine
0.000053
-
-
 Homo sapiens N-([5-[(2R)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methylbiphenyl-2-yl]carbonyl)-L-methionine
0.000055
-
-
 Homo sapiens N-([5-[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methoxybiphenyl-2-yl]carbonyl)-L-methionine
0.000075
-
-
 Homo sapiens N-([5-[(2R)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methylbiphenyl-2-yl]carbonyl)-D-methionine
0.000112
-
-
 Homo sapiens N-([5-[(2R)-2,3-dihydro-1,4-benzodioxin-2-ylmethoxy]-2'-methoxybiphenyl-2-yl]carbonyl)-L-methionine
0.012
-
-
 Homo sapiens N-[(5-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]carbamoyl]-2'-methylbiphenyl-2-yl)carbonyl]-D-methionine
0.016
-
-
 Homo sapiens N-[(5-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]carbamoyl]-2'-methylbiphenyl-2-yl)carbonyl]-L-methionine
0.151
-
-
 Homo sapiens N-[(5-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]carbamoyl]-2'-methoxybiphenyl-2-yl)carbonyl]-L-methionine
0.302
-
-
 Homo sapiens N-[(5-[[(2S)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]carbamoyl]-2'-methoxybiphenyl-2-yl)carbonyl]-D-methionine
0.843
-
-
 Homo sapiens N-[(5-[[(2R)-2,3-dihydro-1,4-benzodioxin-2-ylmethyl]carbamoyl]-2'-methoxybiphenyl-2-yl)carbonyl]-D-methionine