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Literature summary for 2.5.1.58 extracted from
- Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I (2006), J. Lipid Res., 47, 681-699.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ABT-839 | - |
Homo sapiens |  |
| BMS-214662 | - |
Homo sapiens | |
| L-778,123 | - |
Homo sapiens | |
| R115777 | - |
Homo sapiens | |
| SCH66336 | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | required, stabilizes the developing negative charge on the diphosphate as the bond breaks between the a-phosphate and the C1 atom of the farnesyl group | Homo sapiens | |
| Zn2+ | contains one Zn2+ ion per dimer, required for catalysis and peptide binding | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 46000 | - |
1 * 48000 + 1 * 46000 | Homo sapiens |
| 48000 | - |
1 * 48000 + 1 * 46000 | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| farnesyl diphosphate + protein-cysteine | - |
Homo sapiens | diphosphate + S-farnesyl protein | - |
ir | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | 1 * 48000 + 1 * 46000 | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FTase | - |
Homo sapiens |
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